Drugs Affecting Hypothalamic, Pituitary, and Thyroid Function

Question 1

IGF-1

Answer 1

the primary mediator of growth hormone’s effects

Question 2

pegvisomant

Answer 2

growth hormone receptor antagonist used for the treatment of acromegaly

Question 3

dopamine receptor agonists

Answer 3

cabergoline and bromocriptine; cabergoline has a higher affinity and longer half-life

Question 4

growth hormone therapy side effects in children

Answer 4

intracranial HTN, papilledema, visual changes, headache, nausea, committing, leukemia

Question 5

growth hormone therapy side effects in adults

Answer 5

peripheral edema, carpal tunnel syndrome, arthralgia, and myalgia

Question 6

Mecasermin

Answer 6

complex of hIGF-1 and hIGFBP-3 for use in children with IGF-1 deficiency

Question 7

somatostatin analog adverse effects

Answer 7

GI: nausea, diarrhea, abdominal pain

Question 8

somatostatin analogs

Answer 8

octreotide and lanreotide

Question 9

protirelin

Answer 9

stimulates TSH release from the pituitary; used to test thyroid function

Question 10

thyrotropin alpha

Answer 10

hTRH used in diagnostics of thyroglobulin levels

Question 11

levothyroxine

Answer 11

L-T4

Question 12

liothyronine

Answer 12

L-T3

Question 13

liotrix

Answer 13

mixture of L-T3 and L-T4

Question 14

thioureylenes

Answer 14

propylthiouracil and methimazole

Question 15

carbimazole

Answer 15

inhibits iodine organification

Question 16

methimazole and propylthiouracil

Answer 16

inhibit thyroid hormone synthesis by blocking peroxidase-catalyzed reactions, iodination of the tyrosine residues, and coupling of DIT and MIT;
PTU inhibits the conversion of T4 to T3
methimazole has a longer half life

Question 17

methimazole distribution

Answer 17

crosses placenta and gets concentrated in fetal thyroid