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Maddy - CPR II - some pharm > Drugs for Asthma and COPD > Flashcards

Drugs for Asthma and COPD Flashcards

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1
Q

MOA montelukast

A

binds with high affinity and selectivity to the CysLT1 receptor and inhibits the actions of LTD4 at that receptor (without any agonist activity)

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2
Q

benefits of ipratropium

A

poorly absorbed after aerosol administration and therefore is relatively free of systemic atropine-like effects

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3
Q

cautions/warnings of budesonide

A

drug should NOT be used for status asthmaticus or acute episodes of asthma, pts with hypersensitivity to milk proteins also should not take it

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4
Q

MOA terbutaline

A

short acting beta 2 agonist (SABA)

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5
Q

contraindications/warning albuterol

A

paradoxical bronchospasm, deterioration of asthma, CV effects, immediate hypersensitivity rxns

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6
Q

indications terbutaline

A

prophylaxis of bronchospasm associated with asthma, bronchitis, and emphysema

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7
Q

indications for ipratropium

A

bronchodilator for maintenance tx of bronchospasm associated with COPD (chronic bronchitis and emphysema)

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8
Q

cautions/warnings of mometasone

A

NOT used for status asthmaticus or acute eipsodes of asthma, not used for pts with hypersensitivity to milk proteins

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9
Q

MOA metaproterenol

A

short acting beta 2 agonist (SABA)

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10
Q

indications for budesonide

A

maintenance tx for asthma as prophylactic therapy in pts 6 yrs or older

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11
Q

cautions/warnings Zilueton

A

NOT used for acute asthma attacks, not recommended in cases with active liver dz or persistent hepatic function enzyme elevations are more than 3x normal limit

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12
Q

indications for indacaterol and vilanterol

A

treat breathing problems caused by COPD like chronic bronchitis and emphysema

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13
Q

indications for mometasone

A

maintenance tx of asthma as prophylactic therapy in pts 4 yrs or older

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14
Q

indications for fluticasone

A

maintenance tx of asthma as prophylactic therapy in pts 4 yrs or older

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15
Q

cautions/warnings prednisone

A

may lead to hypothalamic-pituitary-adrenal (HPA) axis suppression, monitor patients for Cushing’s syndrome and hyperglycemia

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16
Q

who can take levalbuterol

A

4 yrs and older

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17
Q

indications of beclomethasone

A

maintenance tx for asthma and prophylactic therapy in pts 5 yrs or older, also used in tx for pts who require oral corticosteroid therapy to reduce or eliminate the need for the systemic corticosteroids

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18
Q

indications for salmeterol

A

treatment of asthma and prevention of exercise induced bronchospasm in pts 4 yrs and older, maintenance of bronchospasm in pts with COPD

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19
Q

how are oral corticosteroids administered

A

with SABAs to treat moderate to severe asthma flare ups

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20
Q

indicates for prednisone

A

anti-inflammatory or immunosuppressive agent for many infectious diseases and organ transplants; treatment for endocrine conditions and for palliation of certain neoplasms

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21
Q

MO pirbuterol

A

short acting beta 2 agonist (SABA)

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22
Q

indications for levalbuterol

A

treatment or prevention of bronchospasm with reversible obstructive dz

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23
Q

MOA fometerol

A

long acting beta 2 agonist (SABA)

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24
Q

cautions/warning pirbuterol

A

CV effects in some pts

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25
compare oral vs inhaled corticosteroids side effects
oral corticosteroids are more likely to cause side effects
26
MOA levalbuterol
short acting beta 2 agonist (SABA)
27
contraindications/warning for fomoterol
do not use W/O concomitant use of long term asthma control med like inhaled corticosteroid, increased risk of asthma related hospitalization and death
28
MOA Zileuton
inhibits leukotriene LTB4, LTC4, LTD4, and LTE4 formation by directly inhibiting lipoxygenase in the arachidonic acid pathway
29
MOA zafirlukast
competitive receptor antagonist of leukotriene D4 and E4 (LTD4 and LTE4) which are components of slow reacting substance of anaphylaxis (SRSA)
30
indications for ciclesonide
maintenance tx of asthma as prophylactic therapy in pts 12 yrs or older
31
indications for tiotropium
long term, once daily maintenance tx of bronchospasm associated with COPD
32
indicates for metaproterenol
bronchodilator for bronchial asthma and for reversible bronchospasm that occurs in bronchitis and COPD
33
MOA albuterol
short acting beta 2 agonist (SABA)
34
indications of Zileuton
used as prophylaxis and chronic tx of asthma in adults and children 12 yrs and older
35
cautions/warnings Omalizumab
anaphylaxis (administer only in a healthcare setting)
36
cautions/warnings of traimcinolone
NOT for acute bronchospasm, NOT for status asthmaticus or acute episodes of asthma, when pts are transferring from systemically active corticosteroids --> traimcinolone, need to be careful because there have been deaths due to adrenal insufficiency
37
indications for use of albuterol
asthma, acute bronchitis, COPD, bronchiolitis
38
all LABAs must be used in concomitant use with ____
long term asthma control med like an inhaled corticosteroid
39
indications for pirbuterol
prevention and reversal of bronchospasm
40
what pts can take pirbuterol
12 yrs and older
41
what must happen after withdrawal from systemic corticosteroids
a number of months for recovery of hypothalamic-pituitary adrenal (HPA) function
42
indications zafirlukast
prophylaxis and chronic tx of asthma in adults and children 5 yrs and older
43
cautions/warnings of flunisolide
NOT used for status asthmaticus or acute episodes of asthma
44
indications for flunisolide
maintenance tx of asthma as prophylactic therapy in pts 6 yrs or older, indicated for pts requiring oral corticosteroid therapy b/c adding flunisolide therapy will reduce or eliminate that need
45
MOA olodaterol
long acting beta 2 agonist (SABA)
46
MOA of theophylline
1) blocks PDE, which increases cAMP and causes bronchodilation 2) blocks adenosine, which blocks bronchoconstriction
47
cautions/warnings of ciclesonide
NOT used for acute bronchospasm, pts can get candida infections of mouth and pharynx, other infections
48
cautions/warning levalbuterol
paradoxical bronchospasm
49
cautions/warnings of beclomethasone
when pts are transferring from systemically active corticosteroids --> beclamethasone, need to be careful because there have been deaths due to adrenal insufficiency
50
cautions/warnings montelukast
not indicated for reversal of bronchospasm in acute asthma attacks including status asthmaticus
51
major effects of corticosteroids
switch off the transcription of multiple activated genes that encode inflammatory proteins like cytokines, chemokines, adhesion molecules, and inflammatory enzymes
52
indications for olodaterol
long term, once daily maintenance bronchodilator tx of airflow obstruction in pts with COPD (chronic bronchitis, and emphysema)
53
indications for aclidinium
long term maintenance tx of bronchospasm associated with COPD
54
indications montelukast
treat allergies and prevent asthma attacks
55
risks of long acting beta agonists
asthma related deaths and asthma related hospitalizations
56
MOA leukotriene antagonists (montelukast, zafirlukast, zileuton)
bind to cysteinyl leukotriene (CysLT) receptors and blocks their activation and the subsequent inflammatory cascade which causes sx associated with asthma and allergic rhinitis
57
indications for fomoterol
maintenance tx for broncoconstriction in pts with COPD
58
what is the only beta 2 agonist available by subcutaneous injection
terbutaline
59
cautions/warnings terbutaline
not recommended for pts with tocolysis (uterine contractions)
60
cautions/warnings of fluticasone
NOT used for acute bronchospasm, pts can get candida infections of mouth and pharynx
61
cautions/warning metaproterenol
CV effects in some pts, can produce paradoxical bronchospasm
62
adverse effects terbutaline
headache, nausea, tachycardia, palpitations
63
adverse effects albuterol
HA, dizziness, insomnia, dry mouth, cough
64
MOA salmeterol
long acting beta 2 agonist (SABA)
65
what pts can take terbutaline
12 years and older
66
who can take fomoterol
5 yrs and older as an add on to long term asthma control medication (inhaled corticosteroid)
67
cautions/warnings zafirlukast
hepatotoxicity
68
indications for Omalizumab
moderate to severe persistent asthma in pts 6 yrs and older with positive skin test or in vitro reactivity to a perennial aeroallergen and sx that are not adequately controlled with ICS, also for chronic idiopathic urticaria
69
MOA Omalizumab
anti-IgE antibody
70
cautions/warning atropine
in CAD patients dose needs to be 2-3 mg to avoid atropine-induced tachycardia
71
indications for triamcinolone
maintenance tx of asthma as prophylactic therapy, indicated for pts requiring oral corticosteroid therapy b/c adding triamcinolone therapy will reduce or eliminate that need
72
with what pts must you use extreme caution when prescribing theophylline
pts with active peptic ulcer dz, seizure disorders, and cardiac arrhythmias
73
MOA indacaterol and vilanterol
long acting beta 2 agonist (SABA)

Maddy - CPR II - some pharm (18 decks)

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