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Drugs of Abuse Flashcards

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1
Q

which is a CB1 receptor agonist?

a. opioids
b. cannabinoids
c. LSD
d. mescaline

A

b. cannabinoids

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2
Q

drug used for treatment of alcoholism and opioid addiction

a. naloxone
b. naltrexone
c. methadone
d. buprenorphine

A

b. naltrexone

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3
Q

partial agonist of nicotinic acetylcholine receptor used smoking cessation

a. acamprosate
b. bupropion
c. naloxone
d. varenicline

A

d. varenicline

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4
Q

endogenous cannabinoids

a. 2-arachidonoyl glycerol
b. anandamide
c. both
d. neither

A

c. both

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5
Q

non-selective opioid antagonist and partial agonist used for treating addiction

a. baclofen
b. methadone
c. naltrexone
d. rimonabant

A

c. naltrexone

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6
Q

a recalcitrant, chronic, and stubbornly relapsing disease that is very difficult to treat

a. addiction
b. withdrawal
c. relapse
d. dependence

A

a. addiction

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7
Q

compulsive, relapsing drug use despite negative consequences, at times triggered by cravings that occur in response to contextual cues

a. addiction
b. withdrawal
c. relapse
d. dependence

A

a. addiction

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8
Q

antidote for opioid overdose

a. flumazenil
b. naloxone
c. methadone
d. morphine

A

b. naloxone

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9
Q

antidote for benzodiazepine toxicity

a. flumazenil
b. naloxone
c. methadone
d. morphine

A

b. naloxone

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10
Q

clinically used as cough suppressant

a. morphine
b. nalbuphine
c. dextromethorphan
d. naloxone

A

c. dextromethorphan

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11
Q

Kappa agonist and mu agonist

a. buprenorphine
b. nalbuphine
c. tapentadol
d. tramadol

A

b. nalbuphine

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12
Q

this activates the melanin receptors in suprachiasmatic nuclei

a. ramelteon
b. suvorexant
c. buspirone
d. flumazenil

A

a. ramelteon

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13
Q

thiopental

a. requires a loading dose
b. partial agonist at 5-HT
c. induction agent for anesthesia
d. binds more selectively to Bz receptors

A

c. induction agent for anesthesia

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14
Q

phenobarbital

a. requires a loading dose
b. partial agonist at 5-HT
c. induction agent for anesthesia
d. binds more selectively to Bz receptors

A

a. requires a loading dose

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15
Q

buspirone

a. requires a loading dose
b. partial agonist at 5-HT
c. induction agent for anesthesia
d. binds more selectively to Bz receptors

A

b. partial agonist at 5-HT

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16
Q

zaleplon

a. requires a loading dose
b. partial agonist at 5-HT
c. induction agent for anesthesia
d. binds more selectively to Bz receptors

A

d. binds more selectively to Bz receptors

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17
Q

facilitates GABA-mediated chloride ion channel opening frequency

a. barbiturate
b. benzodiazepene
c. both
d. neither

A

a. barbiturate

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18
Q

binds to GABA-A receptors

a. barbiturate
b. benzodiazepene
c. both
d. neither

A

c. both

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19
Q

oxymorphone

a. mixed agonist-antagonist
b. strong agonist
c. moderate agonist
d. antagonist
e. weak agonist

A

b. strong agonist

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20
Q

naltrexone

a. mixed agonist-antagonist
b. strong agonist
c. moderate agonist
d. antagonist
e. weak agonist

A

d. antagonist

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21
Q

buprenorphine

a. mixed agonist-antagonist
b. strong agonist
c. moderate agonist
d. antagonist
e. weak agonist

A

a. mixed agonist-antagonist

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22
Q

steeper dose response curve

a. barbiturate
b. benzodiazepene
c. both
d. neither

A

a. barbiturate

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23
Q

morphine

a. mixed agonist-antagonist
b. strong agonist
c. moderate agonist
d. antagonist
e. weak agonist

A

b. strong agonist

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24
Q

codeine

a. mixed agonist-antagonist
b. strong agonist
c. moderate agonist
d. antagonist
e. weak agonist

A

c. moderate agonist

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25
nalmefene a. mixed agonist-antagonist b. strong agonist c. moderate agonist d. antagonist e. weak agonist
d. antagonist
26
propoxyphene a. mixed agonist-antagonist b. strong agonist c. moderate agonist d. antagonist e. weak agonist
c. moderate agonist
27
pentazocine a. mixed agonist-antagonist b. strong agonist c. moderate agonist d. antagonist e. weak agonist
a. mixed agonist-antagonist
28
analgesic mechanism a. kappa receptor b. mu receptor c. delta receptor d. all of the above
d. all of the above
29
respiratory depressant action a. kappa receptor b. mu receptor c. delta receptor d. all of the above
b. mu receptor
30
sedative actions a. kappa receptor b. mu receptor c. delta receptor d. all of the above
b. mu receptor
31
benzodiazepine a. acetylcholine receptor agonist b. NMDA receptor agonist c. Dopamine transporter blocker d. reverses serotonin transport e. GABA receptor modulator
e. GABA receptor modulator
32
cocaine a. acetylcholine receptor agonist b. NMDA receptor agonist c. Dopamine transporter blocker d. reverses serotonin transport e. GABA receptor modulator
c. Dopamine transporter blocker
33
ecstasy a. acetylcholine receptor agonist b. NMDA receptor agonist c. Dopamine transporter blocker d. reverses serotonin transport e. GABA receptor modulator
d. reverses serotonin transport
34
nicotine a. acetylcholine receptor agonist b. NMDA receptor agonist c. Dopamine transporter blocker d. reverses serotonin transport e. GABA receptor modulator
a. acetylcholine receptor agonist
35
phenycyclidine a. acetylcholine receptor agonist b. NMDA receptor agonist c. Dopamine transporter blocker d. reverses serotonin transport e. GABA receptor modulator
b. NMDA receptor agonist
36
clinically used for moderate pain a. morphine b. nalbuphine c. dextromethorphan d. naloxone
b. nalbuphine
37
this binds to GABA A receptors a. nicotine b. alcohol c. benzodiazepines d. phencyclidine
c. benzodiazepines
38
this pyrazolopyrimidine is used for sleep disorder a. benzodiazepine b. eszopicione c. zolpidem d. zaleplon
d. zaleplon
39
exogenous cannabinoids a. THC b. CBD c. both d. neither
c. both
40
nonselective opioid antagonist and partial agonist used for treating addiction a. baclofen b. methadone c. naltrexone d. rimonabant
c. naltrexone
41
in substance abuse the old term physical dependence is now known as a. addiction b. withdrawal c. relapse d. dependence
d. dependence
42
which is a serotonin receptor partial agonist a. opioids b. cannabinoids c. LSD d. mescaline
c. LSD
43
THC analog for now used for treatment of chemotherapy-induced emesis a. dronabinol b. nabilone c. methadone d. rimonabant
b. nabilone
44
methadone a. mixed agonist-antagonist b. strong agonist c. moderate agonist d. antagonist e. weak agonist
b. strong agonist
45
oxycodone a. mixed agonist-antagonist b. strong agonist c. moderate agonist d. antagonist e. weak agonist
c. moderate agonist or b. strong agonist
46
nalbuphine a. mixed agonist-antagonist b. strong agonist c. moderate agonist d. antagonist e. weak agonist
a. mixed agonist-antagonist
47
naloxone a. mixed agonist-antagonist b. strong agonist c. moderate agonist d. antagonist e. weak agonist
d. antagonist
48
tramadol a. mixed agonist-antagonist b. strong agonist c. moderate agonist d. antagonist e. weak agonist
e. weak agonist
49
cocaine a. activate g protein-coupled receptors b. bind to ionotropic receptors and ion channels c. bind to transporters of biogenic amines d. all of the given e. none of the given
c. bind to transporters of biogenic amines
50
ecstasy a. activate g protein-coupled receptors b. bind to ionotropic receptors and ion channels c. bind to transporters of biogenic amines d. all of the given e. none of the given
c. bind to transporters of biogenic amines
51
nicotine a. activate g protein-coupled receptors b. bind to ionotropic receptors and ion channels c. bind to transporters of biogenic amines d. all of the given e. none of the given
b. bind to ionotropic receptors and ion channels
52
phencyclidine a. activate g protein-coupled receptors b. bind to ionotropic receptors and ion channels c. bind to transporters of biogenic amines d. all of the given e. none of the given
b. bind to ionotropic receptors and ion channels
53
affinity to mu receptors a. endorphins > enkephalins b. endorphins < enkephalins c. endorphins = enkephalins
a. endorphins > enkephalins
54
affinity to kappa receptors a. endorphins > enkephalins b. endorphins < enkephalins c. endorphins = enkephalins
c. endorphins = enkephalins
55
affinity to delta receptors a. endorphins > enkephalins b. endorphins < enkephalins c. endorphins = enkephalins
b. endorphins < enkephalins
56
alcohol a. activate g protein-coupled receptors b. bind to ionotropic receptors and ion channels c. bind to transporters of biogenic amines d. all of the given e. none of the given
b. bind to ionotropic receptors and ion channels
57
LSD a. activate g protein-coupled receptors b. bind to ionotropic receptors and ion channels c. bind to transporters of biogenic amines d. all of the given e. none of the given
a. activate g protein-coupled receptors
58
amphetamine a. activate g protein-coupled receptors b. bind to ionotropic receptors and ion channels c. bind to transporters of biogenic amines d. all of the given e. none of the given
c. bind to transporters of biogenic amines
59
GHB a. activate g protein-coupled receptors b. bind to ionotropic receptors and ion channels c. bind to transporters of biogenic amines d. all of the given e. none of the given
a. activate g protein-coupled receptors
60
cannabinoids a. activate g protein-coupled receptors b. bind to ionotropic receptors and ion channels c. bind to transporters of biogenic amines d. all of the given e. none of the given
a. activate g protein-coupled receptors
61
ketamine a. activate g protein-coupled receptors b. bind to ionotropic receptors and ion channels c. bind to transporters of biogenic amines d. all of the given e. none of the given
b. bind to ionotropic receptors and ion channels
62
mescaline a. activate g protein-coupled receptors b. bind to ionotropic receptors and ion channels c. bind to transporters of biogenic amines d. all of the given e. none of the given
a. activate g protein-coupled receptors
63
buspirone a. activates the melanin receptors in suprachiasmatic nuclei b. partial serotonin agonist is usec for generalized anxiety states c. blocks orexins that promote sleep onset and duration d. blocks its GABA-A receptor binding site
b. partial serotonin agonist is usec for generalized anxiety states
64
tasimelteon a. Activates the melanin receptors in suprachiasmatic nuclei b. partial serotonin agonist is usec for generalized anxiety states c. blocks orexins that promote sleep onset and duration d. blocks its GABA-A receptor binding site
a. Activates the melanin receptors in suprachiasmatic nuclei
65
ramelteon a. Activates the melanin receptors in suprachiasmatic nuclei b. partial serotonin agonist is usec for generalized anxiety states c. blocks orexins that promote sleep onset and duration d. blocks its GABA-A receptor binding site
a. Activates the melanin receptors in suprachiasmatic nuclei
66
suvorexant a. Activates the melanin receptors in suprachiasmatic nuclei b. partial serotonin agonist is usec for generalized anxiety states c. blocks orexins that promote sleep onset and duration d. blocks its GABA-A receptor binding site
c. blocks orexins that promote sleep onset and duration
67
opioid a. activate g protein-coupled receptors b. bind to ionotropic receptors and ion channels c. bind to transporters of biogenic amines d. all of the given e. none of the given
a. activate g protein-coupled receptors
68
crosses the placental barrier a. barbiturate b. benzodiazepine c. both d. neither
c. both
69
has high affinity to GABA-B receptors a. barbiturate b. benzodiazepine c. both d. neither
d. neither
70
hepatic drug-metabolizing enzyme inducer a. barbiturate b. benzodiazepine c. both d. neither
a. barbiturate
71
clinically used for severe pain a. morphine b. nalbuphine c. dextromethorphan d. naloxone
a. morphine
72
This imidazopyridine is used for sleep disorder a. benzodiazepine b. eszopiclone c. zolpidem d. zalepion
a. benzodiazepine
73
blocks central muscarinic receptors a. amphetamine b. GHB c. Ketamine d. Psilocybin e. Scopolamine
e. Scopolamine
74
blocks DA uptake a. amphetamine b. GHB c. Ketamine d. Psilocybin e. Scopolamine
a. amphetamine
75
disinhibition of DA neurons a. amphetamine b. GHB c. Ketamine d. Psilocybin e. Scopolamine
b. GHB
76
NMDA receptor antagonist a. amphetamine b. GHB c. Ketamine d. Psilocybin e. Scopolamine
c. Ketamine
77
nonaddictive a. amphetamine b. GHB c. Ketamine d. Psilocybin e. Scopolamine
c. Ketamine or d. Psilocybin
78
Mechanism of Action: Nicotine
Acetylcholine receptors
79
Has additive effects with ethanol a. Benzodiazepine b. Barbiturate c. both d. neither
c. both
80
antagonized by flumazenil
Benzodiazepine
81
exerts a calming effect a. sedative b. hypnotic c. both d. neither
a. sedative
82
Adverse effect/s with acute use of opioid analagesics
Urinary retention
83
Adverse effect/s with acute use of opioid analagesics
respiratory depression
84
Clinically used to treat pulmonary edema
morphine
85
Function includes sedation a. mu receptor b. delta receptor c. both d. neither
a. mu receptor
86
Function includes modulation of hormones a. mu receptor b. delta receptor c. both d. neither
c. both
87
Quantitative Comparison of Sedative Hypnotic Dose for CNS effect: a. Anesthesia > Coma b. Anesthesia < Coma c. Anesthesia = Coma
b. Anesthesia < Coma
88
Delta-9-tetra-hydrocannabinol
Marijuana
89
Most addictive drug in the group
opioids
90
Synthetic analog of THC cannabinoid agonist
dronabinol
91
Drugs of abuse that acts on G protein-coupled receptors a. opioids b. cannabinoids c. Hallucinogens d. all of the above
d. all of the above

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