Drugs questions i got wrong

Question 1

What do low molecular weight heparins promote formation of?

Answer 1

Factor X/Antithrombin III complex

Question 2

What does block of platelet ADP receptors by clopidogrel inhibit?

Answer 2

glycoprotein receptor mediated aggregation

Question 3

NSTEMI events can be distinguished from unstable angina by the presence of:

Answer 3

blood markers

Question 4

How might hypertrophic cardiomyopathy lead to diastolic dysfunction?

Answer 4

results in ventricle walls becoming thicker and stiffer

Question 5

Cardiac glycosides contain the following chemical groups:

Answer 5

Lactone group
Steroid group
Sugar

Question 6

steroids useful for treatment in bronchial asthma

Answer 6

• beclometasone
• budesonide
• prednisolone

Question 7

what is bound to glucocorticoid receptors before they bind agonists?

Answer 7

Heat shock proteins

Question 8

Give example of toxin that acts via the neuromuscular nAChR and the organism which produces it.

Answer 8

Epibatidine - Epipedobates tricolor - frog

Botulinum toxin - Clostridium botulinum

Question 9

Give example of toxin that acts via acetylcholinesterase and the organism which produces it.

Answer 9

Huperzine A - chinese firmoss

Physostigma - produced by calabar bean

Question 10

Give example of toxin that acts via the mAChR and the organism which produces it.

Answer 10

Tropane alkaloids (atropine, hyoscine)
Produced by Jimson Weed and belladonna/Deadly nightshade.

Question 11

How many points of attachment does Noradrenaline make with adrenergic receptors?

Answer 11

three, R-NA binds tighter than S-NA

Question 12

What occurs upon receptor interaction with Gq?

Answer 12

IP3 conc. increases.

Causes release of calcium.

Question 13

What stimulates Phospholipase C?

Answer 13

alpha q - GTP

Question 14

What stimulates protein kinase A?

Answer 14

alpha s - GTP

Question 15

Dopamine receptor is under which class

Answer 15

GPCR

Question 16

nAChR is under which class

Answer 16

ligand -gated ion channel

Question 17

GABAa receptors are under which class

Answer 17

ligand gated ion channel

Question 18

Antagonists have zero potency

TRUE/FALSE

Answer 18

FALSE

Question 19

Adrenoreceptor expressed in skeletal muscle?

Answer 19

Beta 2 adrenoreceptor

Question 20

What naturally occurring platelet inhibitor is dipyridamole similar to?

Answer 20

Prostacylcin

Question 21

What would a combination of atorvastatin and ezetimibe result in?

Answer 21

Reduced absorption of dietary cholesterol and reduced synthesis of cholesterol in the liver

Question 22

What is a group of drugs that are agonists at the nuclear hormone receptor PPARα?

Answer 22

Fibrates

Question 23

Drugs in class II of the VW system act primarily at …

Answer 23

β1 adrenoceptors

Question 24

Noradrenaline differs from adrenaline in that it has

Answer 24

one fewer methyl group

Question 25

An enzyme involved in the breakdown of monoamine neurotransmitters in the adrenaline synthesis pathway is

Answer 25

catechol-O-methyltransferase

Question 26

What transport are | nicotinic acetylcholine receptors involved in

Answer 26

active transport of cations, powered by hydrolysis

Question 27

NA reversing slowing of the heart produced by activation of mAChRs is an example of what type of antagonism.

Answer 27

Functional antagonism as NA itself is an agonist.

Question 28

Blockade of which adrenoreceptor produces dilation of blood vessels

Answer 28

alpha 1

Question 29

What is a naturally occurring inhibitor of the clotting cascade?

Answer 29

Heparin

Question 30

What channel does ω-agatoxin block?

Answer 30

P-type channels.

Question 31

Theophylline targets

Answer 31

adenosine receptors and phosphodiesterases

Question 32

What drug can't be used if a patient has hypokalaemia

Answer 32

Digoxin

Question 33

How long after allergen contact before the inflammatory phase of bronchial asthma occurs

Answer 33

6 hours

Question 34

Mast granules contain

Answer 34

Proteases | histamine

Question 35

Late mediators required by mast cells

Answer 35

Prostaglandins | Leukotrienes

Question 36

Where is ACE primarily produced?

Answer 36

Juxtaglomerular apparatus

Question 37

What enzyme does aliskiren target?

Answer 37

Renin

Question 38

clinical trial that demonstrated Ca2+channel blockers and ACE inhibitors to be superior to beta blockers and diuretics

Answer 38

ASCOT trial

Question 39

Reynaud’s phenomenon can be precipitated by which class of antihypertensive drugs

Answer 39

Beta Blockers

Question 40

Which drug class results in reduced levels of bradykinin?

Answer 40

ACE inhibitors

Question 41

Where do local anaesthetics primarily act?

Answer 41

Sodium channels

Question 42

Unfractionated heparins bind directly to

Answer 42

anti-thrombin III factor IIa thrombin

Question 43

Glucocorticoid receptors are found where

Answer 43

NHRs found in the cytoplasm

Question 44

anti-asthmatic effect of beclometasone is due to actions at what receptors

Answer 44

Intracellular hormone receptors

Question 45

What receptor does theophylline antagonise?

Answer 45

adenosine A1 receptor

Question 46

How does ezetimibe lower LDL levels?

Answer 46

Inhibit proteins in the gut

Question 47

What AChR is gated by a neurotransmitter?

Answer 47

mAChR

Question 48

Clinical trial that demonstrated the superiority of Ca channel blocking drugs over Beta blockers was the

Answer 48

ASCOT trial