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Immuno spring 2016 > E2 practice > Flashcards

Flashcards in E2 practice Deck (72)
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1

T/F In order for T helper and CTLs to function they must be activated.

True

2

T-Helper cells activated by ______ on ______

T-Helpers activated by MHC II on APCs

3

CTL's (killer T cells) activated by _____ on _______

CTL's activated by MHC I by “most cells in the body”

4

Which major histocompatibility complex protein presents antigen to activate T helper cells?

MHC II - asssociated with CD4 and T helper cells

5

Which major histocompatibility complex protein presents antigen to activate CTL's (Killer T cells?)

MHC I - associated with CD8 and Killer T cells (CTL's)

6

Infected antigen presenting cells displaying viral protein on MHC I function to activate primarily which of the following?

CTL's (Killer T cells)

7

What keeps the immune system from overreacting?

Regulatory T cells

8

What is the function of CD3 in a T cell receptor?

intracellular signaling

9

Traditional T cells express what receptors?

Αβ (95%)

10

Non traditional T cells express what receptors?

γδ

11

What T cell co receptor is associated with CTLs and functions to strengthen attachment of the TCR to MHC?

CD8

12

What T cell co receptor is associated with ALL T cells and functions as a protein signaling complex

CD3

13

What T cell co receptor is associated with T helper cells

CD4

14

when you see CTL's you should think ___

CD8

15

what is a receptor molecule on the T Cell Which when activated it amplifies the signal and lower the # of TCR crosslinks needed for activation

CD28

16

T/F Immature T cells in the thymus only express CD3.

False
Double Positive – majority expressing both CD4 + CD8, TCR

17

What allows experienced T cells to reactivate without co stimulation?

Maintenance of lipid rafts

Once T Cells are activated by co-stim, many more cholesterol lipid rafts form. The lipid rafts contain numbers of signaling molecules. “once a cell is activated, it is easier to reactivate- experienced T cells are easier to activate” –written in

18

would up regulation of B7 allow experienced T cells to reactivate without co stimulation?

No, B7 is a co stimulatory molecule

19

Would up regulation of CTLA-4 allow experienced T cells to reactivate without co stimulation?

No, CTLA-4 binds to B7 making it harder to reactivate T cells

20

Th2 bias is normally geared for which of the following?

Parasitic attack in GI tract

Parasitic attack or food contaminated with pathogenic bacteria

21

Th1 bias is normally geared for which of the following?

Viral attack in respiratory tract

Th1 bias typically viral/bacterial

22

Th17 bias is normally geared for which of the following?

Fungal attack in respiratory tract

Fungal attack and some extracellular bacteria

23

Besides a Fas ligand on its cell surface, how else can a CTL kill its target?

Perforin/granzyme B

(Perferates the cell, and drops in the “suicide note”)

1-Attaches, Granzyme B introduced → suicide
2- CTL Fas Ligand to Fas protein → suicide

24

Which of the following is an example of a secondary lymphoid organ?

Lymph node, Spleen, Peyers patches

25

Which of the following is an example of a primary lymphoid organ?

Bone marrow, and Thymus

26

Which of the following best describes a primary lymphoid follicle?

Island of follicular dendritic cells in a sea of B cells

27

Follicular dendritic cells have receptors that bind which of the following? (pick two)

Compliment protein + Fc region of antibodies

FDCs attach and hold opsonized antigens – allows BCRs cluster and crosslink more easily

28

What is characteristic of the antigen that follicular dendritic cells catch and display to B cells?

Its opsonized

29

In a lymph node, proliferating B cells are associated with which of the following?

Germinal center

30

In a Light Zone, proliferating B cells are associated with which of the following?

Fab regions + hypermutation