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Immuno spring 2016 > Exam I > Flashcards

Flashcards in Exam I Deck (81)
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1

The largest physical Barrier to be defended is the Mucous membranes? (T/F)

True

2

The largest physical Barrier to be defended is the skin? (T/F)

False

3

Commensal Microbiota in the gut compete with pathogens for nutrients and attachment sits? (T/F)

True

4

Lysozyme, defensins, cathelicidins and histatins are all examples of?

Antimicrobial enzymes/peptides

5

IL-1, IL-6, TNF-alpha are a classic example of?

Pro-inflamatory Cytokines.

6

Thick or impaired mucus flow predisposes an individual to what?

Chronic infection. (ex. Cystic Fibrosis)

7

If the inflammation response is not regulated it can lead to?

Sepsis or septic shock

8

What cells of the immune system are prolific cytokine factories?

T helper Cells.

9

What cell acts as a liaison between the innate and adaptive immune system?

Dendritic Cells

10

Inflammation is an Adaptive immune response?(T/F)

False

11

Inflammation is an Innate immune response?(T/F)

True

12

Which of the following is not a function of antibodies?

Apoptosis

13

Do antibodies directly kill cells?

No

14

What are the functions of antibodies?

Neutrilization
Opsonization
Complement Activation
Antibody-Dependent Cell Mediated Cytotoxicity

15

What are the functions of the complement system?

Opsinization
Chemical Attractant
Destroys Bacteria

16

Does the complement system require activation?

Yes

17

What are the 3 pathways that activate the complement system?

Alternative Pathway
Lectin Pathway
Classical Pathway (Antibody dependant)

18

What Cells Present antibodies?

Activated Dendritic Cells
Activated Macrophages
Activated B Cells
Activated Neutrophils

19

What is the Function of C3a and C5a?

Chemo attractant

20

What is the fucntion of C5b, C3b?

Bind to the cell membrane

21

What is the Function of Convertase? (C3bBb)

split more C3 and C5

22

What forms the Membrane Attack complex?

C5b, C6, C7, C8, C9

23

What is the most numerous white blood cell in the body?

Neutrophil

24

What Monosaccharide found on the surface of many pathogens can trigger the activation of complement?

Mannose

25

When Mannose is found on the surface of many pathogens trigger the activation of complement is is called?

Lectin Activation Pathway

*mannose binding lectin protein and MASP, clips locale C3 to C3a, and C3b*

26

What professional phagocyte normally circulates in the blood?

Neutrophil

27

What professional phagocyte normally circulates in the tissue?

Macrophages

28

What is the least numerous white blood cell in the body?

Basophil

29

What are the characteristics of a primed macrophage?

phagocytosis (big bites)
expreses MHC II
Produces comeplement proteins C3, factor B, Factor D
Proiliferates

30

What are the characteristics of a resting macrophage?

phagocytosis (small Bites)
Slowly Proiliferates
Few MHC II's displayed