EBV – infectious mononucleosis

Question 1

Complications of EBV

Answer 1

-infectious Mononucleosis [90%]
-Nasopharyngeal Carcinoma-
-. Burkitt Lymphoma [a type of NHL ]

Question 2

Most common Complication of EBV

Answer 2

infectious Mononucleosis [90%

Question 3

Most common complication of infectious Mononucleosis →

Answer 3

Splenic Hemorrhage
(However according to Medexam it is Headache]
** Those px. Should NOT play Sport b/c ↑ risk for splenic rupture

Question 4

Px. Take Amoxicillin and develop Rash →

Answer 4

infectious mononucleosis

Question 5

Keywords:

Answer 5

Generalized lymphadenopathy [90% of cases]. - Pharynx is erythematous & Hypertrophied [Tonsillopharyngitis] - Fever ! ; also you can see Hepatosplenomegaly

Question 6

Labs

Answer 6

Leukocytosis , atypical lymphocytes in Blood smear

Question 7

Diagnosis

Answer 7

1. Initial Test
   Monospot Test -POSITIVE [i.e. there is Heterophile antibodies] indicate acute infection ; if positive no need for
   further investigation
2. If we suspected IM but Monospot is negative then check: → Anti-EBV antibodies
   There is 2 Tests:
   I. Anti-VCA antibodies IgM [Viral capsid antigen] – POSITIVE indicate Acute infection
   II. Anti- EBNA antibody IgG [EBV nuclear antigen] – POSITIVE indicate Past infection
3. Culturing a throat swab shows EBV → indicate Chronic infection

Question 8

Treatment

Answer 8

• mainly supportive [IV. Fluids ] b/c self-limited disease- However, complicated cases → steroids can be considered [help when there is airway
  obstruction] - if myocarditis occur [Rare complication] → Beta blocker or ACE-I ]