Eckert: Growth Flashcards

(39 cards)

1
Q

Mid-parental height
Females
Males

A

MH + (PH-13)/2

(MH+13) + PH/2

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2
Q

Generally children’s heights will be within (blank) standard deviations of MPH

A

1.5

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3
Q

What three things do growth charts measure?

A

height, weight, OFC

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4
Q

If weight is more affected than height, what are some problems that come to mind?

A

GI, nutritional, renal, metabolic, CF

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5
Q

If height is more affected than weight, what are some of the problems that come to mind?

A

generally constitutional, endocrine/syndromic, renal, metabolic

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6
Q

When the head circumference is most affected, what can this indicate?

A

neurologic/genetic problem

endocrine unlikely

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7
Q

When does bone age become reliable?

A

3 years

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8
Q
Wall mounted stadiometer
Fixed platform
Heels to the wall, chin up and supported
Measure 3 times and average
Be sure to plot appropriately depending on disorders, race, etc.
A

Important components for growth evaluation

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9
Q

Most helpful for determining height potential

A

bone age

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10
Q

When growth velocity is normal and bone age combined with height yield a normal predicted height, what is most likely occuring?

A

most likely is constitutional delay of growth and puberty

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11
Q

Incidence of constitutional delay of growth and puberty

A

males: 1/7500
females: 1/50,000

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12
Q

Kids must be growing (blank) cm/year to imply normal growth velocity

A

5-7cm

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13
Q

What age defines delayed puberty in males and females?

A

> 14yrs

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14
Q

Puberty generally starts when bone age is (blank) in females and (blank) in males

A

10; 12

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15
Q

What kinds of things should be considered if growth velocity is abnormal and height prediction is out of keeping with genetics?

A

mediciations (ADD, steroids, others)
GI issues (celiac, nutrition)
hypothyroidism, GH deficiency, adrenal insufficiency/hyperplasia
syndromes - Turner, Cushings

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16
Q

If there’s a short girl, what should you do?

17
Q

Tests that can be performed if bone growth, etc is inappropriate?

A
CMP
CBC
TSH
IGF-1
IGF-BP-3
karyotype
celiac panel
LH/FSH
estradiol/testosterone
18
Q

What should be done if hormone deficiency is found?

A

MRI of pituitary

19
Q
What's this pituitary hormone deficiency?
Most common isolated deficiency
IGF-1, BP-3 low
Growth velocity slow
Bone age delay
Hypoglycemia, fatigue, slow mentation
A

GH deficiency

20
Q

Hx neonatal hypoglycemia, jaundice, microphallus
Poor growth, delayed puberty
Fatigue, constipation, polyuria, polydipsia
Developmental Delay
+/- Appetite, sleeping issues
Diabetes insipidus

A

hypopituitarism

21
Q

May be associated with septo-optic dysplasia, midline defects, single central incisor
Low free T4 (nl TSH), adrenal function tests, osmolality, low IGF-1, BP-3

A

hypopituitarism

22
Q

How common is Turner syndrome?

A

1/2500 live births

23
Q

Consider this is ANY short female

A

Turner syndrome

24
Q

Major signs of Turner syndrome

A
short stature
cardiac abnormalities
renal abnormalities
hypothyroidism
celiac disease
diabetes
25
Short stature, macrocephaly, micrognathia, asymmetric limbs, precocious puberty, scoliosis, FTT, hypoglycemia as infant
Russell-Silver Syndrome
26
“male Turner” right sided cardiac defects, neck webbing, hypogonadism
Noonans syndrome
27
FTT, hypotonia as infant, excessive weight gain after 1st year of life
Prader-Willi syndrome
28
Cushings syndrome is extremely rare. What's the more common cause? What are the symptoms?
exogenous steroids | short stature, rapid weight gain, hypertension, striae, buffalo hump, may be delayed puberty
29
How to test for Cushings syndrome?
salivary cortisol; AM cortisol; ACTH; 24 hours urine for free cortisol
30
Unexplained neonatal hypoglycemia, jaundice, microphallus Early signs of hypopituitarism, including GHD Unexplained, abnormally slow or fast growth Persistent growth velocity 95th% for age Extreme short stature (>2.5 SD) (or extreme tall) Growth pattern and prognosis at variance with family Height projection differs significantly from MPH Detection of abnormal body proportion
When to refer a patient
31
Tall stature is rarely refferred. What can cause it?
exogenous obesity precocious puberty syndromes (Marfan's) GH secreting tumor in children
32
What two growth factors are produced by the liver?
IGF-1 | IGF-BPI
33
Prenatal growth rate
~2cm a week with peak at midgestation
34
What two things strongly affect prenatal growth? | What two things do not have a strong affect?
IGF-1 Nutritional/maternal factors GH and T4
35
Infant/toddlerhood growth rate
15-25cm per year
36
What things strongly influence growth in infancy/toddlerhood
GH and T4 and nutrition!!
37
During childhood, what is the growth rate? | What are important factors?
5-7cm | hormones, genetic, nutrition
38
During puberty, what is the growth rate? What is most important here?
15cm/year | HORMONES
39
Things involved in normal growth
``` hormones nutrition GI abdnormalities genetics environment ```