Sertoli cells Flashcards
(17 cards)
Sertoli cells are the primary target for what two things? In this way, they are the primary regulators of spermatogenesis.
testosterone; androgens
Sertoli cells form up this barrier to protect against autoimmune response and drugs, toxins
blood testis barrier
Sertoli cells establish (blank) for development
microenvironment (think about the blood testis barrier isolating the maturing sperm cells)
During spermiogenesis, sertoli cells phagocytose excess (blank)
cytoplasm
FSH stimulates Sertoli cells to secrete this to concentrate T in tubules
androgen binding protein
Sertoli cells secrete THIS to control FSH production
Inhibin
So how are inhibin and ABP and FSH related?
So, FSH stimulates secretion of ABP. If there is enough ABP, sertoli cells secrete inhibin to inhibit further FSH production from occuring
Sertoli cells produce THIS to promote regression of the paramesonephric ducts in the male
anti-Mullerian hormone
Sertoli cells secrete stuff that initiates meiosis
true
Sertoli cells secrete THIS which is additive to semen
testicular fluid
Sertoli cells also synthesize and secrete these two things
testicular transferrin; plasminogen activator
Secrete hormones affecting pituitary gland control of spermatogenesis, particularly this polypeptide hormone
inhibin
Testosterone is needed in very high quantities for maintenance of the reproductive tract, and (blank) allows a much higher level of fertility
ABP
All Sertoli cells are (blank)
contiguous
What kind of cells are Sertoli cells? What do they lie on? Do they reach the lumen?
columnar cells; on basement membrane; reach the lumen
Create these two microenvironments
adlumenal and basal
Do Sertoli cells form junctional complexes between themselves and developing spermatogonia?
yes
