Ectoparasite control Flashcards
(72 cards)
Give an example where you may intervene at multiple stages of a parasites life cycle?
fleas:
- adulticide to animal
- spray environment to affect juvenile stages
Why might it be more effective to target certain stages of a parasite’s life cycle?
Some stages, like larvae (e.g., blowfly strike), are more vulnerable than adults.
What two key characteristics of a parasite are essential to know when deciding which animals to treat?
If the parasite is contagious to others of the same species
If the parasite is species-specific
What are two non-chemical control strategies for ectoparasites?
Avoiding contact with the parasite
Producing conditions unsuitable for the parasite to live or reproduce
How can contact with parasite be avoided (non-chemical)?
barriers
Most useful where only part of life cycle on host, so harder to control
How can conditions be made unsuitable for parasite to live/reproduce (non-chemical)
Change host environment
- e.g., minimise pasture worm burden/ tail docking => reduce myiasis of sheep
Change off-host environment
- e.g., management of dung to avoid attracting flies
What public health implications may influence ectoparasite treatment?
Zoonosis (e.g., sarcoptic mange)
Parasites as disease vectors (e.g., ticks transmitting Lyme disease).
What are some methods used in chemical ectoparasite control?
Neurotoxins (kill parasite)
Insect growth regulators (arrest parasite development)
Repellents, desiccants, and mechanical agents
What drug-related factors need to be considered when choosing a drug for ectoparasite control?
Spectrum of activity (what parasite at which life stage)
Speed of onset required
Duration of action/frequency of application (compliance, animals that get wet)
Contraindications and drug interactions
Safety (patient, owner and humans, environment, non-target species)
Development of resistance
Cost and licensing (many are expensive and POM-V)
What host-related factors need to be considered when choosing a drug for ectoparasite control?
species
age restrictions
suitable mode of application
meat/milk withdrawal periods (production animals)
Describe the action of neurotoxins
Most ectoparasiticides
Act of CNS synapses, axons or neuromuscular junctions => spastic or flaccid paralysis
All adulticidal & some ovicidal/larvicidal also
What extra safety considerations should we be aware of when using neurotoxins?
Insects and mammals have many neurotransmitters in common – better safety profile if drugs act on non-mammalian mechanisms
Give examples of different types of neurotoxins & their action.
Describe Neonicatinoids & give an example.
Nicotinic acetylcholine (Ach) receptor stimulant
Used for fleas in small animals
examples:
- Imidacloprid (topical application)
- Nitenpyram
- Dinotefuran
Describe organophosphates & give an example.
Cholinesterase inhibitors
example:
- diazinon (dimpylate) (sheep dip vs wide range of ectoparasites)
Describe phenylpyrazoles & give an example.
GABA inhibitors
against fleas & ticks
example:
- Fipronil (topical application, toxic to rabbits)
Describe Isoxazolines & give an example.
GABA + chloride channel inhibitors
fleas & ticks
Rapid onset of action
- kills fleas before eggs laid so most likely to be effective if environmental treatment not feasible
Absorbed systemically
Caution in patients with seizure history
Examples:
- Fluralaner
- Sarolaner
- Afoxolaner
Describe Macrocyclic lactones & give an example.
Chloride channel stimulator
Absorbed systemically
Ectoparasites & endoparasites
cause neurotoxicity in collies/herding breeds (MDR1 gene mutation)
Describe Pyrethroids & give examples.
Sodium channel stimulant
adulticide for fleas, flies, lice, keds, ticks & some mites
Also repellant
Toxic to cats & aquatic life
Examples:
- Permethrin
- Cypermethrin
- Deltamethrin
- Fluemethrin
What stage of life cycle do insect growth regulators act on?
interrupt juvenile stage (no adulticidal properties)
- very slow to act
- often used in conjunction with rapid acting adulticide
What are the 3 types of insect growth regulators
Juvenile hormone analogues
Chitin synthesis inhibitors
Triazine derivatives
Describe juvenile hormone analogues & give an example.
Mimic activity of juvenile hormone so development of egg/larva arrested
Commonly in environmental flea sprays (also collars & spot-ons)
examples:
- S-methoprene
- Pyriproxyfen
- Fenoxycarb
Describe chitin synthesis inhibitors & give an example.
Prevent normal development of the exoskeleton –> stop larvae developing
All dogs/cats in household must be treated for product to work
example:
- Lufenuron
Describe Triazine derivatives & give an example.
Disrupt cuticle turnover – moult inhibitors
Preferential efficacy for Dipteran fly larvae –> prevention of cutaneous myiasis (sheep and rabbits)
examples:
- Cyromazine
- Dicyclanil
