Neonate & mammary gland Flashcards

(46 cards)

1
Q

Why are neonates more susceptible to disease than adults?

A

Poor breathing
Limited ability to regulate body temperature
Poor regulation of fluid balance
Limited energy store
Immune system is immature

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2
Q

What are the key challenges faced by neonates?

A

Increased susceptibility to disease

Poor response to disease (rapid hypothermia, rapid fluid loss, energy depletion & poor immunological response)

Potential for high mortality rate

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3
Q

How do neonates acquire maternal antibodies?

A

Some antibodies cross placenta, while others are obtained from colostrum

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4
Q

How is MDA transfer different in dogs?

A

Limited trans-placental transfer; most MDA comes from colostrum

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5
Q

Why must colostrum intake occur within a few hours after birth?

A

Because absorption efficiency drops from 60% before 4 hours to only 5% after 12 hours

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6
Q

What are common causes of FPT?

A

Poor quality colostrum
- Early lactation & colostral loss
- Primiparous dams
- Mastitis
- Poor udder development
- Lack of maternal antibodies

Poor neonatal intake

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7
Q

What are the consequences of FPT?

A

Increased risk of GI disease, respiratory disease, joint sepsis, umbilical abscess, fading puppy syndrome, sepsis, increased mortality, poor weight gain & high antibiotic use

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8
Q

How can FPT be treated?

A

Donor colostrum or hyperimmune plasma administration (not always successful)

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9
Q

What are the keys aspects of ongoing care for neonates?

A

Ensuring colostrum & milk intake

Ensuring hydration status

Monitoring environmental temperature & pup behaviour

Regular clinical examination

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10
Q

What are some other immune deficiencies affecting neonates?

A

Hypogammaglobulinemia, congenital SCID, agammaglobulinemia, selective IgM deficiency & Fell Pony Immune Deficiency Syndrome

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11
Q

When do neonates with immune deficiencies typically show symptoms?

A

After maternal antibodies wane, leading to increased susceptibility to disease

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12
Q

What is APGAR scoring?

A

System that evaluates neonates in 5 areas, with score <6 predicting poor survival

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13
Q

What are early indicators of neonatal illness?

A

Frequent crying, failure to gain weight, cold touch, inelastic skin, slack abdomen, dirty coat, loss of body twitching, & delayed development

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14
Q

What are common clinical signs of neonatal sepsis?

A
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15
Q

What are some clinical signs of premature foals?

A

<320d gestation
Low birth weight
Silky hair coat
Domed forehead
Floppy ears
Flexor laxity/hypotonia
Weak suck reflex
Poor thermoregulation
Entropion
Poor glucose regulation
Immature renal function

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16
Q

What are common causes of neonatal illness in pups?

A

Managemental & maternal causes, very low birth weight & congenital defects

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17
Q

What are key aspects of neonatal care for sick pups?

A

Early supplemental feeding, ensuring colostrum intake, monitoring body temperature, maintaining hydration, weight recordings & environmental monitoring

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18
Q

What are signs of dehydration in neonates?

A

Coloured urine, poor skin elasticity, dry mucous membranes & slow capillary refill time

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19
Q

What are essential monitoring parameters for sick neonates?

A

Rectal temp, urine colour, skin elasticity, mucous membrane colour, resp rate & heart rate

20
Q

At what temperature should neonatal pups be maintained?

A

29-32°C (slightly higher than normal)

21
Q

Why should you not feed a hypothermic pup (<24°C)?

A

Because digestion is impaired, leading to potential complications

22
Q

What supportive treatments can be used in critical neonates?

A

Oxygen administration (via incubator or tracheal catheter), slow re-warming (1°C per hour) & dextrose supplementation

23
Q

How does high MDA affect vaccination?

A

High levels of maternal antibodies can interfere with vaccine effectiveness

24
Q

What aspects should be examined in a mammary gland assessment?

A

Skin
Gland structure (size, texture, firmness, evenness)
Teat & teat canal condition (ulceration, discharge)
Milk quality (colour, odour, production levels)

25
What additional tests can be used to assess mammary gland health?
California Mastitis Test, ultrasound, fine needle aspiration
26
What does a positive California Mastitis Test (CMT) indicate?
Presence of somatic cells (WBCs), which suggests mastitis
27
What are the characteristics of a normal mammary gland?
Healthy skin Normal size Functional suspensory system No pain or heat Even texture Normal milk production
28
How does progesterone affect the mammary gland?
Causes mammary enlargement in non-pregnant dogs, often leading to pseudo-pregnancy
29
What are common mammary disorders?
Skin diseases (e.g. warts or ulcerative mammillitis (BHV2)) Udder suspensory damage Teat trauma Inverted nipples Mastitis Hyperplasia Neoplasia Agalactia
30
What is mastitis, and how is it classified?
Inflammation of mammary gland Types include: - Subclinical - Clinical - Acute - Acute gangrenous (tissue necrosis) - Chronic
31
What are common causes of mammary hyperplasia?
Normal under progesterone Due to milk engorgement at weaning Mammary hyperplasia (e.g hormonally induced in Queen with fibroepithelial hyperplasia)
32
What percentage of mammary tumours are malignant in dogs?
50% (with up to 50% of these metastasising by diagnosis)
33
What percentage of mammary tumours are malignant in cats?
85%
34
How is mammary neoplasia staged using the TNM system?
T (Tumor size) N (Node involvement) M (Metastasis presence) E.g.: 4 cm tumour with no lymph node spread & no lung metastasis = T2, N0, M0 (Stage 2)
35
What are the two types of agalactia?
1. Failure of milk production – Due to inadequate mammary development (e.g. early C-section) 2. Failure of milk letdown – Due to stress-induced adrenaline blocking oxytocin release
36
How is agalactia treated?
Milk production failure: Metoclopramide (prolactin agonist) Milk letdown failure: Oxytocin administration Infections causing agalactia (e.g. metritis, mastitis): Treat underlying disease
37
What is the minimum IgG concentration considered "good quality" colostrum?
50 mg/ml IgG (or Brix 22%)
38
What factors can impact colostrum quality?
Nutrition of dam, vaccination status, time from birth to first milking, storage conditions
39
What threshold of total protein (TP) indicates successful passive transfer?
≥5.2 g/L TP (Brix 8.4% or serum IgG >10 g/L)
40
What are key steps in immediate neonatal care?
Ensure breathing, check standing ability, navel management, colostrum intake, drying & warmth
41
How can you stimulate respiration in a neonate?
Rub with towels, use straw or needle in nostril, place in sternal recumbency
42
What are key steps in thermoregulation of neonates?
Drying, providing clean bedding, heat lamps & warm colostrum intake
43
Why is increasing blood volume (colostrum) important for struggling neonates?
Helps correct acidosis & improves circulation to vital organs
44
What does meconium staining indicate?
Foetal distress during birth
45
What issues could a swollen tongue or head in neonates cause?
Could result in neuro deficit - brain swelling => can affect ability to feed - not able to suckle effectively
46
What can be investigated to prevent further problems?
Colostrum quality & management Test scour Post mortem BVD vaccine status Hygiene