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STEP 2 > ED: Drug Side Effects > Flashcards

ED: Drug Side Effects Flashcards

(57 cards)

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1
Q

ACE Inhibitors

A

Cough, rash, proteinuria, angioedema, taste changes, teratogenic effects

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2
Q

Amantadine

A

Ataxia, livedo reticularis

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3
Q

Aminoglycosides

A

Ototoxicity, nephrotoxicity (acute tubular necrosis)

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4
Q

Amiodarone

A

Acute: AV block, hypotension, bradycardia. Chronic: pulmonary fibrosis, peripheral deposition leading to bluish discoloration, arrhtyhmias, hypo/hyperthyroidism, corneal deposition

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5
Q

Amphotericin

A

Fevers/rigors, nephrotoxicity, bone marrow suppression, anemia

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6
Q

Antipsychotics

A

Sedation, acute dystonic reaction, akathisia, parkinsonism, tardive dyskinesia, NMS

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7
Q

Azoles

A

Inhibition of P-450 enzymes

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8
Q

AZT

A

Thrombocytopenia, megaloblastic anemia

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9
Q

Beta Blockers

A

Asthma exacerbation, masking of hypoglycemia, impotence, bradycardia, AV block, CHF

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10
Q

Benzodiazepines

A

Sedation, dependence, respiratory depression

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11
Q

Bile acid resins

A

GI upset, malabsorption of vitamins and medications

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12
Q

Carbamazepine

A

Induction of P450 enzymes, agranulocytosis, aplastic anemia, liver toxicity

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13
Q

Calcium channel blockers

A

Peripheral edema, constipation, cardiac depression

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14
Q

Chloramphenicol

A

Gray baby syndrome, aplastic anemia

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15
Q

Cisplatin

A

Nephrotoxicity, acoustic nerve damage

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16
Q

Clonidine

A

Dry mouth; severe rebound headache and hypertension

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17
Q

Clozapine

A

Agranulocytosis

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18
Q

Corticosteroids

A

Mania; hyperglycemia (acute), immunosuppression, bone mineral loss, thinning of skin, easy bruising, myopathy, cataracts (chronic)

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19
Q

Cyclophosphamide

A

Myelosuppression, hemorrhagic cystitis

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20
Q

Digoxin

A

GI disturbance, yellow visual changes, arrhythmias

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21
Q

Doxorubicin

A

Cardiotoxicity (cardiomyopathy)

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22
Q

Ethyl alcohol

A

Acidosis, renal dysfunction, CNS depression

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23
Q

Fluoroquinolones

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A

Cartilage damage in children; achilles tendon rupture in adults

24
Q

Furosemide

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A

Ototoxicity, hypokalemia, nephritis, gout

25
Gemfibrozil
Myositis, reversible increase in LFTs
26
Halothane
Hepatotoxicity, malignant hyperthermia
27
HCTZ
Hypokalemia, hyponatremia, hyperglycemia, hyperlipidemia, hyperuricemia, hypercalcemia (hyperGLUC)
28
Statins
Myositis, reversible increase in LFTs
29
Hydralazine
Drug-induced SLE
30
Hydroxychloroquine
Retinopathy
31
INH
Peripheral neuropathy (prevent with pyridoxine/vitamin B6), hepatotoxicity, inhibition of P450s, seizures with overdose, hemolysis in G6PD deficiency
32
MAOIs
Hypertensive tyramine reaction, serotonin syndrome (with meperidine)
33
Methanol
Blindness, ion-gap metabolic acidosis
34
Methotrexate
Hepatic fibrosis, pneumonitis, anemia
35
Methyldopa
+ coombs test, drug induced SLE
36
Metronidazole
Disulfiram reaction, vestibular dysfunction, metallic taste
37
Niacin
Cutaneous flushing
38
Nitroglycerin
Hypotension, tachycardia, headache, tolerance
39
Penicillamine
Drug-induced SLE
40
Penicillin/Beta Lactams
Hypersensitivity Reactions
41
Phenytoin
Nystagmus, diplopia, ataxia, arrhythmia (in toxic doses), gingival hyperplasia, hirsutism, teratogenic effects
42
Prazosin
First dose hypotension
43
Procainamide
Drug-induced SLE
44
Propylthiouracil
Agranulocytosis, aplastic anemia
45
Quinidine
Cinchonism (headache, tinnitus), thrombocytopenia, arryhthmias (torsades)
46
Reserpine
Depression
47
Rifampin
Induction of P450 enzymes; orange-red body secretions
48
Salicylates
Fever; hyperventilation with respiratory alkalosis and metabolic acidosis; dehydration, diaphoresis, hemorrhagic gastritis
49
SSRIs
Anxiety, sexual dysfunction, serotonin syndrome if taken with MAOIs
50
Succinylcholine
Malignant hyperthermia, hyperkalemia
51
TCAs
Sedation, coma, anticholinergic effects, seizures, QRS prolongation, arrhythmias
52
Tetracyclines
Tooth discoloration, photosensitivity, Fanconi's syndrome, GI distress
53
Trimethoprim
Megaloblastic anemia, leukopenia, granulocytopenia
54
Valproic Acid
Teratogenicity leads to neural tube defects; rare fatal hepatotoxicity
55
Vancomycine
Nephrotoxicity, ototoxicity, red man syndrome (histamine release)
56
Vinblastine
Severe myelosuppression
57
Vincristine
Peripheral neuropathy, paralytic ileus

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