Endo

Question 1

Initial levothyroxine dose for hypothyroidism

Answer 1

1.6ug/kg/day
Reduce to 25-50ug/day if patient is old and has cardiovascular disease

Question 2

Chronic use of opioid or methadone can cause secondary hypogonadism and increased prolactin level

Question 3

Sglt2 inhibitor should be cautious in patient with

Answer 3

Previous amputation, severe peripheral neuropathy, severe peripheral vascular disease or active diabetic foot ulcer or soft tissue infections.

Question 4

When will we do screening pheo in incidental adrenal mass

Answer 4

When density of the mass more than 10 hounsfield

Question 5

Which antibodies in Hashimoto thyroiditis

Answer 5

Thyroid peroxidase antibodies

Question 6

Urine calcium-creatinine ratio determination is used to diagnosed

Answer 6

Familial hypocalciuric hypercalcemia
PTH level is elevated

Question 7

Test in graves disease

Answer 7

Thyroid stimulating immunoglobulin and thyrotropin receptor antibodies

Question 8

Glp1 receptor antagonist just reduce risk of atherosclerotic cardiovascular disease and diabetic kidney disease. Contraindicated in history of pancreatitis and not reduce risk of heart failure related hospitalization

Question 9

Side effect of teriparatide

Answer 9

Increase in bone osteosarcoma

Question 10

Inferior petrosal sinus sampling used to diagnose cushing disease by checking acth level in the inferior petrosal sinus with periphery after administration of corticotropin releasing hormone

Question 11

Progestin can cause bone loss when use alone. If combine with estrogen will decrease bone loss

Question 12

Virilization symptom

Answer 12

Voice deepening, clitoromegaly, male patterm baldness, severe acne

Question 13

Hirsutism

Answer 13

Thick coarse dark hair in upper lip, chin, and side of the face

Question 14

Active warming can cause ???

Answer 14

Vasodilation and can cause hypotension

Question 15

When treating myxedema, if a random cortisol is more than… do not need to give hydrocortisone

Answer 15

18

Question 16

Marker for monitoring papillary thyroid cancer

Answer 16

Serum thyroglobulin and thyroglobulin antibody

Question 17

Treat type 2 amiodarone induce thyrotoxicosis and symptomatic thyroid tenderness from thyroiditis

Answer 17

Prednisone

Question 18

Teprotumumab is a monoclonal antibody to insulin like growth factor 1 receptor, uses to treat

Answer 18

Moderate to severe graves ophthalmopathy

Question 19

Treatment of primary hyperparathyroidism and concurrent osteoporosis, unable to undergo surgery

Answer 19

Alendronate

Question 20

Pituitary infiltrative disorder caused by sarcoidosis and Langerhans cell histiocytosis

Answer 20

Can cause deficiency of anterior pituitary hormones and arginine vasopressin deficiency

Question 21

How many types of amiodarone induce thyroiditis and how to differentiate

Answer 21

Type 1 AIT on graves and thyroid nodules, treat with methimazole
Type 2 AIT called destructive thyroiditis treated with glucocorticoid
Differentiate by ultrasound. Increase vascularity is type 1, decrease vascularity is type 2

Question 22

Which circumstances to check free t3

Answer 22

1: evaluation of thyrotoxicosis to identify isolated t3 toxicosis
2: assess the severity of hyperthyroidism and response to therapy
3: to potentially differentiate hyperthyroidism from destructive thyroiditis

Question 23

Contrandication of raloxifen

Answer 23

High risk for fracture and history of cardiovascular disease

Question 24

Contraindication of romosozumab: mixed anabolic and antiresorptive effect

Answer 24

History of cardiocascular disease

Question 25

Teriparatide is an anabolic agent used for postmenopausal women at high risk osteoporotic fracture. If start subsequent to denosumab discontinuation, it will stimulate the bone resorption associated with denosumab

Question 26

Positive plasma aldosterone concentration/plasma renin activity in primary aldosteronism

Answer 26

Ratio greater than 20 with plasma aldosterone concentration of at least 15 ng/dl

Question 27

When do we consider pheochromocytoma

Answer 27

When nodule density is more than 10 hounsfield units

Question 28

How is plasma renin activity on patient uses acei and arb

Answer 28

Plasma renin activity is elevated. If pra is low, suspect primary hyperaldosteronism

Question 29

Confirmatory test for primary hyperaldosteronism

Answer 29

Aldosteron measurement after oral sodium loading or saline suppression test. Aldosteron level need to be suppressed after loading with sodium

Question 30

How to distinguish renal and extrarenal of potassium loss

Answer 30

Check 24-hour potassium creatinine ratio or spot urine potassium creatinine ratio. If less than 13 meq/g it is extrarenal.

Question 31

In acromegaly, if IGF-1 is elevated, what to do next

Answer 31

Oral glucose tolerance test to confirm the diagnosis

Question 32

How high is GH after oral glucose tolerance test to diagnose

Answer 32

Normal is less than 0.2 ng/ml Diagnostic is more than 1 ng/ml

Question 33

Aldosterone also has direct inflammatory and fibrotic effects