Hematology

Question 1

Treat pure red cell aplasia in an immunocompromised patient

Answer 1

Iv ig

Question 2

Who treats with proteasome inhibitor like bortezomib should receive antiviral prophylaxis like acyclovir valalcyclovir

Question 3

Abx prophylaxis with bactrim and levofloxacin is given during induction chemo because of gram negative and encapsulated bacteria

Question 4

Elevated serum homocysteine level can indicate folate deficiency if normal serum folate level and also increase in vit b12 deficiency

Question 5

Auer rods found in AML especially Acute promyelocytic leukemia

Question 6

Increase methylmalonic acid indicate vitamin b12 deficiency

Question 7

Lithium steroid granulocyte colony stimulating factor can cause elevated wbc

Question 8

High risk polycythenia vera can be treated with hydroxyurea, interferon alpha, ruxolitinib, frequent phlebitomy

Question 9

Adverse effect off g csf

Answer 9

Transient leukopenia following administration, flulike symptoms, hypertension, increase risk for thrombosis, stimulation of malignancy, production of neutralizing antibodies

Question 10

Fluoroquinolone prophylaxis used when allogebeic stem cell transplantation, induction chemotherapy for acute leukemia

Question 11

Acute lymphocytic leukemia survivor can increase risk for AML and MDS

Question 12

Intrathecal chemotherapy and whole brain irradiation will be done routinely in acute lymphoblastic leukemia

Question 13

Mucin secreting pancreatic adenocarcinoma can cause dic

Question 14

Ivig is useful for pure red cell aplasia

Question 15

Ruxolitinib is an jak1/jak2 inhibitor approved for Polycythenia vera and myelofibrosis

Question 16

Antidote of dabigatran idarucizumab
Antidote of apixaban , rivaroxaban endoxaban is andexanet alpha and 4fpcc

Question 17

Antithrombin iii, protein s and protein c will be reduced in an acute vte

Question 18

Paroxysmal nocturnal hemoglobinuria is defected of PIGA gene. Could present with intravascular hemolysis or venous and arterial thrombosis

Question 19

Evolocumab act against complement component c5 and inhibits complement activation to treat paroxysmal nocturnal hematuria and atypical HUS

Question 20

Replased/refractory acute lymphoblastic leukemia can be treated by chimeric antigen receptor t cell car t cell therapy

Question 21

Dabigatran, endoxaban need bridge by heparine

Question 22

If treatment for cold agglutinin needed, we can use rituximab

Question 23

Frequent dosing of oral iron two to three times a day can increase hepcidine and decrease iron absorption

Question 24

Treat vte on esrd on hemodialysis by apixaban

Question 25

Apixaban dosing 10mg bid for 7 days then 5 mg bid

Question 26

Evans syndrome include autoimmune hemolytic anemia and ITP

Question 27

Peripheral blood smear show spherocyte in warm autoimmune hemolytic anemia, and erythrocyte agglutination in cold agglutinin disease

Question 28

Superficial venous thrombosis with provoked or unprovoked treat with ac in 6 weeks

Question 29

Therapeutic target of thalassemia is hgb 9.5 to 10.5

Question 30

Differentiate liver disease and dic is factor 8 because factor 8 is produce by the liver and the endothelial cell. If it is low then dic, if it is normal then liver disease

Question 31

Denatured globin chains attached to the erythrocyte membrane called Heinz bodies in G6PD deficiency

Question 32

Atithymocyte globulin and cyclosporine are used to treat aplastic anemia in pt younger than 65

Question 33

Lenalidomide used to treat MDS with 5q-