Endo

Question 1

FSH action in both males and females

Answer 1

Males - stimulates Sertoli cells to produce Sperm

Females
- stimulates growth of follicles
- stimulates prod of oestrogen by Granulosa cells (inner follicle) by converting androgens received from theca cells

Question 2

LH action in both males and females

Answer 2

Males - stimulates leydig cells to produce testosterone

Females
- stimulates ovulation
- stimulates prod of androgens by theca cells (outer follicle) - then converted into oestrogen by granulosa cells
- stimulates development of corpus luteum - produces progesterone after ovulation

Question 3

Tanner stages of pubic hair growth (5)

Answer 3

1 - nil
2 - sparse, long, slighty pigmented, downy
3 - spreads, darker, coarser
4 - adult-like but smaller area, confined to triangle
5 - adult, spreads to medial thighs

Question 4

Mx of
a) central DI
b) nephrogenic DI

c) dx

d) What should one be wary of with anterior and posterior dysfunction?

e) Drug cause of nephrogenic DI?

Answer 4

a) DDAVP = desmopressin
b) thiazide diuretics

c) water deprivation test: plasma osmolality > 290 with inappropriately low urine osmolality —-> given DDAVP

d) cortisol needed to excrete water (?by ADH inhibition). In combined anterior and posterior pit dysfunction, if there is cortisol deficiency and DDAVP is given due to lack of vesmopressin —-> could lead to dilutional hyponatraemia.