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Physiology II > Endocrine > Flashcards

Endocrine Flashcards

0
Q

steroid hormone synthesis & storage

A

synthesized from cholesterol

not stored- synthesized as they are needed

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1
Q

storage of peptide hormones?

secretion mechanism of peptide hormones?

A

stored in vesicles

elevated cAMP & Ca2+ due to a stimulus results in exocytosis

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2
Q

anterior pituitary hormones (7)

A

TSH
ACTH
GH
LH, FSH, MSH, Prolactin

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3
Q

which pituitary is connected to the hypothalamus via a portal vein?

A

anterior pituitary

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4
Q

posterior pituitary hormones (2)

A

ADH & Oxytocin

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5
Q

stimulation of oxytocin secretion

A

suckling, other baby stuff

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6
Q

signal for GH synthesis & release?

A

GHRH

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7
Q

direct effect of growth hormone

A

maintaining plasma glucose

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8
Q

effect of IGF release

A

increased somatic cell growth

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9
Q

direct effects of GH? (3)

A

increased AA uptake & incorporation into protein
decrease glucose uptake by tissues, increase in liver glucose
increased lipolysis

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10
Q

3 main targets of GH

A

adipose
liver
muscle

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11
Q

indirect effects of GH (4)

A

increased IGF secretion
increased linear long bone growth
increased protein synthesis
organ hypertrophy & hyperplasia

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12
Q

IGF-1 effects of GH? (2)

A

increased somatostatin release

decreased GH release

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13
Q

GHRH regulation?

A

inhibits its own release at the hypthalamus

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14
Q

GH regulation? (4)

A

inhibits its own secretion at the anterior pituitary
increases IGF release, which inhibits GH release from anterior pit.
increases somatostatin release, which inhibits GH
hypothalamus senses plasma glucose levels

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15
Q

site of thyroid hormone synthesis

site of thyroid hormone storage

A

synthesized in follicular cell

stored in the lumen/colloid

16
Q

what modulates activity of iodide uptake

A

iodide trap is modulated by diet: low iodide intake, high trap activity

17
Q

iodide oxidation: transporter and oxidation enzyme

A

transported by pendrin

oxidized by thyroid peroxidase

18
Q

stimulator of thyroid hormone secretion?

A

TSH

19
Q

negative feedback for thyroid hormone secretion (3)

A

hypothalamic dopamine & somatostatin
T3 downregulates TRH receptor
T3 decreases TSH synthesis

20
Q

metabolic effects of thyroid hormone (4)

A

increased BMR
increased O2 consumption
increased body temp.
increased Na-K-ATPase pump activity

21
Q

thyroid hormone cardio effects (3)

A

increased CO
increased ventilation
increased contractility

22
Q

thyroid hormone SNS effect?

A

increased synthesis of B-adrenergic receptors in skeletal mm. and adipocytes

Physiology II (4 decks)

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