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Mark's PEARLS > Endocrine and Metabolic Drugs > Flashcards

Endocrine and Metabolic Drugs Flashcards

(49 cards)

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1
Q

HYPOTHALAMIC-PITUITARY:

Treatment of genetic short stature, failure to thrive

A

Somatropin

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2
Q

Treatment of acromegaly, variceal bleeding

A

Somatostatin — Ocreotide

Hypothalamic-pituitary drugs

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3
Q

Treatment of hyperprolactinemia, prolactinoma

A

Bromocriptine

Hypothalamic-pituitary drugs

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4
Q

Hypothalamic-pituitary drugs

for Labor induction / augmentation
control of postpartum hemorrhage
Milk LETDOWN

SE: fluid retention

A

Oxytocin

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5
Q

Hypothalamic-pituitary drugs

treatment of central diabetes insipidus

A

Desmopressin/ ADH

*nephrogenic: thiazides

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6
Q

Hypothalamic-pituitary drugs used for Nephrogenic DI

A

Thiazides

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7
Q

Thyroid drug

treatment of hypothyroidism and myxedema coma

A

Levothyroxine

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8
Q

Thyroid drug

inhibits thyroid peroxidase
blocks peripheral conversion of T4 - T3
DOC in pregnant hyperthyroid patients

SE: agranulocytosis and hepatitis(prolonged used)

A

Propylthiouracil (PTU)

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9
Q

Thyroid drug

inhibits thyroid peroxidase

SE: agranulocytosis, teratogen (aplastic crisis)

A

Methimazole

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10
Q

Preferred treatment for hyperthyroidism

SE: permanent hypothyroidism

A

RAI

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11
Q

Thyroid drug:

reduces size and vascularity of thyroid gland

A

SSKI

Lugol’s solution

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12
Q

Symptomatic treatment of hyperthyroidism

decreases peripheral conversion of T4 - T3

A

Propranolol

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13
Q

Differentiate Wolf-Chaikoff effect from Jos-basedow phenomenon.

A

Wolf-Chaikoff effect: ingestion of iodine causes HYPOthyroidism

Jod-Basedow phenomenon: ingestion of iodine causes HYPERthyroidism

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14
Q

Which antithyroid drug inhibit PERIPHERAL conversion of T4 - T3?

A

PTU
Propranolol
Hydrocortisone

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15
Q

What drugs can cause drug-induced hyperthyroidism?

A

CAM magka hyperthy ka!

Clonifibrate
Amiodarone
Methadone

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16
Q

Corticosteroid

Used for acute adrenal insufficiency, status asthmaticus, and thyroid storm

A

Hydrocortisone

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17
Q

Prototype oral glucocorticoid
SE: adrenal suppression
Cushing syndrome

A

Prednisone

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18
Q

Corticosteroid that hastens fetal lung maturation

A

Betamethasone/ Dexa

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19
Q

Corticosteroid

used as mineralocorticoid replacement for chronic adrenal insufficiency
Addison disease

A

Fludrocortisone

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20
Q

Female Gonadal hormone

most frequently used as synthetic estrogen in OCPs

SE: hypertension, DVT/PE, endometrial Ca
Contraindication: women (age >35) who are heavy smokers

Study These Flashcards
A

Ethinyl Estradiol

21
Q

Female Gonadal hormone

SE: clear cell vaginal adenoCa in daughther

22
Q

Female Gonadal hormone that prevents estrogen-induced endometrial Ca

SE: weight gain

Study These Flashcards
A

Norgestrel

Progesterone

23
Q

Female Gonadal hormone

OCP of choice in lactating women, amenorrhea

Study These Flashcards
A

Depo-Provera

DMPA

24
Q

Female Gonadal hormone used in Hormone-responsive breast Ca (ER +)

SE: endometrial Ca

25
Female Gonadal hormone used in ovulation induction SE: multiple pregnancies and low grade ovarian Ca
Clomiphene
26
Female Gonadal hormone used as treatment of endometriosis
Danazole
27
Female Gonadal hormone used in medical abortion
Mifepristone
28
Male gonadal hormone treatment of male hypogonadism SE: virilization and paradoxical feminization
Testosterone
29
Male gonadal hormone Used as anabolic steroids and illegal performance enhancer
Oxandrolone
30
Male gonadal hormone treatment of prostate cancer Co-administered to prevent acute flare-ups of tumor
Flutamide (testoterone antagonist) + Leuprolide (GnrH agonist)
31
Male gonadal hormone 5-a reductase inhibitor treatment of BPH and male pattern blindness
Finasteride
32
ANTI-DM: Most efficacious anti-diabetic drug activates tyrosine kinase SE: hypoglycemia and lipodystrophy
Insulin
33
ANTI-DM: 1st generation Sulfonylurea Closing ATP sensitive K channel — increasing insulin secretion SE: Hypoglycemia, weight gain, disulfiram reaction, hyperemic flush
Chlorpropamide Tolbutaminide Tolazamide
34
ANTI-DM: 2nd generation Sulfonylurea Depolarization of beta cell SE: hypoglycemia, weight gain, Disulfiram reaction Cholestatic jaundice(glibenclamide)
``` Glipizide Glyburide Glimepiride Gliclazide Glibenclamide ```
35
ANTI-DM: Newer insulin secretagogue NO hypoglycemia
Repaglinide Nateglinide Mitiglinide
36
ANTI-DM: First line anti-diabetic drug Inhibit renal and liver gluconeogenesis/ endogenous glucose production Stimulates glucose uptake and glycolysis in peripheral tissues SE: lactic acidosis, weight loss, GI upset, vitamin B12 malabsorption DOC for obese diabetic
Metformin
37
ANTI-DM: TZD acts on PPAR-y insulin sensitizer SE: CHF and bladder cancer CI: pregnancy, CLD and CHF
Thiazolidinedione - Pioglitazone - Rosiglitazone - Troglitazone
38
ANTI-DM: a-glucosidase inhibitor SE: flatulence and diarrhea
Acarbose Miglitol Voglibose
39
Anti-diabetic agent DPP4 Inhibitor that degrades GLP-1 amd other incretin — raises circulating GLP1 SE: pancreatitis and nasopharyngitis
Sitagliptin
40
Anti-diabetic agent Incretin modulator GLP-1 Analogue Produces satiety SE: weight loss and hypoglycemia
Exenatide Liraglutide Albiglutide Dulaglutide
41
Why is there paradoxical improvement of diabetes in patients with ESRD?
Insulin has prolonged half-life due to decreased clearance
42
Which patients are more prone to developing hypoglycemia with insulin use?
PRONE TO HYPOGLYCEMIA Advance renal disease Elderly Children younger than 7 years
43
DRUG FOR BONE MET: Inactive vitamin D treatment of rickets and oateomalacia
Ergocalciferol | cholecalciferol
44
DRUG FOR BONE MET: Activate Vitamin D treatment of secondary hyperparathyroidism
Calcitriol | 1, 25
45
DRUG FOR BONE MET: Treatment of Paget’s disease of bone and hypercalcemia Used for tumor marker for medullary thyroid Ca
Calcitonin
46
DRUG FOR BONE MET: Suppresses osteoclastic activity treatment of Paget’s disease of bone and osteoporosis SE: esophagitis
Alendronate Class: Bisphosphate
47
DRUG FOR BONE MET: Phosphate-binding resin
Sevelamer
48
ANTI-DM: Rapid acting insulin
LISPRO LISpro = mabiLIS
49
ANTI-DM: Ultra long acting insulin
LANTus = LANTa na sa sobrang tagal! gLARGine = Go LARGe

Mark's PEARLS (24 decks)

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