Endocrine tumors Flashcards Preview

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Flashcards in Endocrine tumors Deck (14)
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1

MEN1

Pituitary, pancreatic (e.g. ZES, insulinoma), parathyroid hyperplasia

2

MEN2A

Medullary thyroid cancer, pheochromocytoma, parathyroid hyperplasia

3

MEN2B

Medullary thyroid cancer, pheochromocytoma, mucosal neuromas, Marfanoid habitus

4

Insulinoma

Assoc with MEN1, causes hypoglycemia. Lab results: hypoglycemia w/ high insulin, high c-peptide, high proinsulin

5

Labs values in surreptitious insulin use

Hypoglycemia w/ high insulin, low c-peptide, low proinsulin

6

Lab values in sulfonylurea overuse

Hypoglycemia w/ high insulin, high c-peptide, normal proinsulin

7

Zollinger-Ellison syndrome (gastrinoma) features

Tumor of pancreatic islet cells, secreting gastrin --> gastric acid hypersecretion --> ulcers. 60% are malignant, 20% are assoc with MEN1

8

How does ZES cause diarrhea?

Acid inactivates pancreatic enzymes --> steatorrhea

9

Diagnosis of ZES

Secretin injection --> will fail to inhibit gastin levels in ZES
Serum gastrin levels > 1000 diagnostic

10

Glucagonoma (pancreatic tumor) features

DVT (hyperviscous blood)
Dermatitis: **necrotizing migratory erythema**
Diabetes (mild-hyperglycemia)
Depression

11

Somatostatinoma (pancreatic tumor) features

Rare malignant tumor with poor prognosis

**Gallstones, diabetes, steatorrhea**

12

Pathophys of somatostatinoma features

The generalized inhibition of gastrointestinal hormones results in restriction of gallbladder contractility, pancreatic exocrine function, and intestinal secretion and motility

13

VIPoma (pancreatic tumor) features

Watery diarrhea, achlorhydria (VIP inhibits gastric acid secretion), hyperglycemia, hypercalcemia

Can be a part of MEN1

14

How does VIPoma cause diarrhea?

VIP is a potent stimulator of gut cyclic adenosine monophosphate (cAMP) production, which leads to massive secretion of water and electrolytes (mainly potassium).