EndocrInology, Diabetes, Metabolic Medicine Flashcards
(11 cards)
What is clomifene used for?
First-line treatment for fertility issues in the context of PCOS
PCOS stands for Polycystic Ovary Syndrome, a common hormonal disorder affecting women of reproductive age.
How does clomifene compare to gonadotropins in terms of ovarian hyperstimulation syndrome?
Clomifene has a lower risk of inducing ovarian hyperstimulation syndrome compared to gonadotropins
Ovarian hyperstimulation syndrome is a condition that can occur in women undergoing fertility treatments, characterized by swollen and painful ovaries.
What is the definitive management of primary hyperparathyroidism?
Total parathyroidectomy
This is the surgical procedure indicated for confirmed cases of primary hyperparathyroidism.
When should a patient be referred for surgery if primary hyperparathyroidism is confirmed?
If the patient has:
* Symptomatic Hypercalcaemia (Polydipsia, Polyuria, Constipation)
* End-Organ Damage (Osteoporosis, Fragility fracture, Nephrolithiasis)
* Albumin-adjusted serum calcium ≥ 2.85 mmol/L
These symptoms and conditions indicate the need for surgical intervention.
Fill in the blank: The albumin-adjusted serum calcium level that indicates surgery for primary hyperparathyroidism is _______.
≥ 2.85 mmol/L
This threshold helps determine the need for surgical management.
What is cinacalcet?
A calcimimetic that binds the calcium-sensing transmembrane receptor on the parathyroid gland.
How does cinacalcet affect the parathyroid gland?
It makes the parathyroid gland more sensitive to serum calcium levels.
What is a key advantage of cinacalcet over vitamin D?
It does not induce hypercalcaemia.
In which condition is cinacalcet used?
Management of primary hyperparathyroidism when surgery is not an option or declined.
True or False: Cinacalcet causes hypercalcaemia.
False
Fill in the blank: Cinacalcet is used when surgery for primary hyperparathyroidism is _______.
not an option or declined
