Haematology

Question 1

What translocation is Follicular lymphoma driven by?

Answer 1

A translocation involving Ig heavy chain on chromosome 14 and BCL2 on chromosome 18

Follicular lymphoma is a type of non-Hodgkin lymphoma characterized by the overexpression of the BCL2 protein due to this genetic alteration.

Question 2

What is the translocation associated with chronic myeloid leukaemia?

Answer 2

t(9;22)

This translocation creates the BCR-ABL fusion gene, which is a key driver of chronic myeloid leukaemia.

Question 3

Which translocation is associated with Burkitt lymphoma?

Answer 3

t(8;14)

This translocation leads to the overexpression of the MYC oncogene, contributing to the aggressive nature of Burkitt lymphoma.

Question 4

What translocation is linked to mantle cell lymphoma?

Answer 4

t(11;14)

This translocation results in the overexpression of cyclin D1, which plays a critical role in cell cycle regulation.

Question 5

What is the translocation associated with acute promyelocytic leukaemia?

Answer 5

t(15;17)

This translocation results in the formation of the PML-RARA fusion protein, which is crucial for the pathogenesis of acute promyelocytic leukaemia.