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Human Disease AKA Nickey > Endorine Pathology > Flashcards

Endorine Pathology Flashcards

1
Q

What is prolactinoma?

A

Amenorrhea, and infertility

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2
Q

What is Somatotroph

A

Kids Giantism
Adult acromegaly

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3
Q

What is Corticotroph?

A

Cushing disease

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4
Q

what is hormonally non functional?

A

Mass effect headaches

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5
Q
A

Left have multiple grape cells
Cancer you loose that and have uniform on the right

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6
Q

What is Graves’ disease?

A

Common of hyperthyroidism
T4 and T3 excess and hypermetabolic state
TSH is low so we have to look at thyroid itself
Enlarged thyroid gland bc of antibodies that attached to TSH
Higher in women then men

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7
Q

What is Hashimoto disease?

A

hypothyroidism
more common in women
CD4 and CD8 destroy the thyroid gland
Decrease T4 and T3 with increase in TSH

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8
Q
A

Left destroyed thyroid follicles
Right lymphocytic infiltrates

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9
Q

How does a goiter form?

A

Decrease iodine and decrease T3 adn T4 and increase TSH = you get a goiter

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10
Q

What is a papillary Thyroid Carcinoma?

A

85% of cancers with a 95% survival
Lazy cancer
DERIVED FROM FOLLICULAR EPITHELIAL CELLS

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11
Q
A

papillary carcinomas they are empty nuclei and are cauliflower looking

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12
Q

Does metastases mean death for papillary cancer?

A

No the spreading is fine

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13
Q

What is a follicular carcinoma?

A

15% of thyroid cancer
To spread thought the blood
Capsular invasion defines Carcinoma vs adenoma

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14
Q

What does the Parathyroid gland do?

A

Takes order form calcium levels
Control calcium from the bones

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15
Q

What is Hyperparathyroidism?

A

One of the 4 develope hyper function
Over production of calcium that make kidney stone, gall stones, and peptic ulcer

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16
Q

Zona glomerulosa secretes what?

A

Aldosterone

17
Q

Zona fasciculata secretes what?

A

Cortisol

18
Q

Zona Reticularis secretes what?

A

Estrogen and androgen

19
Q

Where does hyperadrenalism come from?

A

Zona Glomerulosa - too much renin and thus you get hypertension

20
Q

What is secondary hyperaldosteronism?

A

Kidney dmg or reduced blood flow

21
Q

What is hypercortisolism come from?

A

Zona Fasiculata - secrete cortisol
And you get Cushing syndrome

22
Q

Causes of crushing syndrome?

A
  1. Drugs
  2. Pituitary adenoma
  3. Adrenal cancer
  4. Ectopic ACTH
23
Q

Chronic adrenocortical insufficiency?

A

Slow autoimmune adrenalitis
Addison disease - skin getting darker

24
Q

What is the adrenal medulla

A

Sits on the bottom of the to of the kidney

25
Q

Pheochromocytoma

A

Epinephrine secreting tumor that creates HTN
Pheochromocytoma of the Adrenal medulla

Human Disease AKA Nickey (8 decks)

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