Flashcards in Endrocrinolgy of Excercise and Stress Deck (18):
What are the effects of norepinephrine and epinephrine on insulin?
Inhibits the release of insulin so that GLUT-4 cannot uptake glucose and GLUT-1 in muscle cells can take glucose still
Effects of muscle contraction and glycogenolysis?
Contraction leads to increased Ca ions; Ca ions bind to calmodulin which then directly activates phosphorylase kinase increasing glycogen degradation
What occurs to the RAAS axis during exercise?
Increase in aldosterone renin and ANP at 25-40% VO2 max
A-II and ADH increase at 60-80% VO2 max
What occurs to the HPA axis with exercise?
During stress of exercise: IL-6 increases-> increase in CRH and AVP -> ACTH
What does the increase of CRH, cortisol and beta-endorphin cause in exercise?
CRH inhibits GnRH and therefore LH and FSH
What does IL-6 cause?
Stimulation of CRH and ADH secretion leading to cortisol release
What is the female athlete triad that leads to exercise induced amenorrhea?
What does extensive exercise cause in males?
Suppression of LH and testosterone levels
What is the term for healthy homeostasis?
What is term for different homeostasis?
What is the term for defective homeostasis?
What part of the brain does the stress system activate?
Hippocampus: Anger and memory
What is the locus ceruleus?
Adrenal gland of the CNS
Where is the locus ceruleus located?
Dorsal wall of the pons
What does the locus ceruleus produce?
NE in the brain
What occurs in fight or flight?
Locus ceruleus releases NE in the brain and it only circulates in the brain
Cortisol effects on the immune system?
Promotes of neutrophil movement from bone marrow to circulation
Reduces lymphocytes in circulation to spleen, thymus, bone marrow