Enteropathogenic Bacterial Infections

Question 1

Vibrio cholera causes pandemics via 
A.contaminated drinking water
B.fecal contamination
C.skin penetration
D.all of the above

Answer 1

A

Question 2

Cholera toxin causes passage of stool with the ff characteristics except
A. rice watery look
B. rotten fish door
C. bloody accompaniment
D. none of the above

Answer 2

C

Question 3

Cholera toxin has __ subunits

Answer 3

5

Question 4

Which subunit/s cause adhesion?

Answer 4

4 beta subunit

Question 5

Which subunit/s cause signal transduction?

Answer 5

1 alpha subunit

Question 6

End effect: affects __ –> effusion of chloride ions from intracellular compartment to extracellular compartment –> water goes with the ions (loss of water)

Answer 6

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Question 7

Cholera is self limiting disease, all that has to be done is ___

Answer 7

fluid replacement

Question 8

false about Campylobacter jejuni
A.mode of transmission: skin penetration
B.Usually seen in uncooked chicken, unpasteurized milk and contaminated water
C.Causes a form of nonspecific watery diarrhoea
D.diagnosis is through stool exam

Answer 8

A

Question 9

false about histopathology (C.jejuni)
A.Mucosal and intraepithelial neutrophils
B.RBCs in crypts
C.both are false
D.both are true

Answer 9

B

WBC dapat

Question 10

T or F

Shigella is a gram (-), unencapsulated, motile bacteria that can resist acidic environment of stomach

Answer 10

F

non-motile dapat

Question 11

False about Shigellosis
A)Potent and infective
B)Initial dysentery but not mild self-limited diarrhea 
C)causes ulceration and haemorrhage
D)none of the above

Answer 11

B

both are caused

Question 12

Shiga toxin inhibits __ synthesis leading to cell death

Answer 12

eukaryotic protein

Question 13

T or F

Antidiarrheal medications are contraindicated because they can prolong symptoms and delay Shigella clearance

Answer 13

T

Question 14

Which is false?

a. There is no vaccine for typhoidal cases of diarrhoea
b. Humans are the sole reservoir
c. both are false
d. both are true

Answer 14

A

Question 15

In S.enterica infection, there is hyperplasia of Peyer’s patches. This may mimic __

Answer 15

appendicitis

Question 16

small erythematous maculopapular lesions on chest and abdomen found in patients with S.enterica

Answer 16

Rose spots

Question 17

False about Yersinia
A.involves ileum, appendix, and right colon
B.can mimic acute appendicitis
C.symptoms:arthralgia and erythema nodosum
D.virulence enhanced by calcium

Answer 17

D

Iron dapat

Question 18

T or F

Salmonella enteritidis causes typhoid

Answer 18

F

Question 19

strain of E.coli which has heat-labile and heat-stable toxins

Answer 19

Enterotoxigenic

Question 20

Heat-stable toxin of ETEC binds to ___ to increase cGMP

Answer 20

guanylate cyclase

Question 21

Which has this virulence: attaching/effacing mechanism --> microvilli
A. ETEC
B. EPEC
C. EIEC
D. all of the above

Answer 21

B

Question 22

Cows are natural reservoir for
A. EIEC
B. EPEC
C. ETEC
D. EHEC

Answer 22

D

Question 23

Official name of EHEC

Answer 23

E. coli O157:H7

Question 24

Type of E.coli with Shiga-like toxin
A. EHEC
B. EIEC
C. ETEC
D. all of the above

Answer 24

A

Question 25

``` Similar to Shigella biologically, no toxins in virulence A. EHEC B. EIEC C. EAEC D. all of the above ```

Answer 25

B

Question 26

``` Which has dispersin? A. EHEC B. EIEC C. EAEC D. all of the above ```

Answer 26

C

Question 27

What does dispersin do?

Answer 27

neutralizes negative surface chargeof LPS

Question 28

Toxins --> ribosylation of ___ -->disruption of the epithelial cytoskeleton, tight junction barrier loss, cytokine release, and apoptosis This is the pathogenesis of C.difficile. Fill in the blanks

Answer 28

small GTPases(Rho)

Question 29

identify Made up of anadherent layers of inflammatory cells and debris at sites of colonic mucosal injury

Answer 29

pseudomembranes

Question 30

In pseudomembranous colitis, there are distended crypts due to ___

Answer 30

mucopurulent exudate

Question 31

causative agent of Whipple disease

Answer 31

Tropheryma whippeli

Question 32

morphology of Tropheryma whippeli A. Gram (+) actinomycete B. Gram (-) actinomycete C. acid fast actinomycete

Answer 32

A

Question 33

post-morten exam manic of Whipple disease

Answer 33

presence of foamy macrophages and many argyrophilic rods in lymph nodes

Question 34

``` false about Tropheryma whippeli A.Periodic Acid-Schiff (PAS)-positive B.acid fast positive C.Gram positive D. none of the above ```

Answer 34

B

Question 35

``` Areas of bacteria-laden macrophages accumulation include all except: A.Mesenteric lymph vessels B.Synovial membranes of affected joints C.Cardiac valves D.Brain ```

Answer 35

A nodes, not vessels