Enzyme Inhibition Flashcards Preview

MCAT biochemistry > Enzyme Inhibition > Flashcards

Flashcards in Enzyme Inhibition Deck (15):
1

a reverse inhibitor is a substance that

binds to an enzyme to inhibit it but can be released (non-covalent bonding)

2

competitive inhibitors are molecules that

compete with the substrate for binding at the active site of an enzyme

3

in competitive inhibition, Km

increases

4

in competitive inhibition, Vmax

unchanged

5

competitive inhibition can be overcome by

adding more substrate so that the concentration is high enough so that it can outcompete the inhibitor
reason why Vmax is not effected

6

noncompetitive inhibitors are molecules that

bind at an allosteric site (NOT the active site) and inhibits the enzyme by changing it's confirmation

7

in noncompetitive inhibition, Km

unchanged

8

in noncompetitive inhibition, Vmax

decreases

9

irreversible inhibition is a

substrate that causes inhibition that cannot be reversed
it usually involves the formation or breaking of covalent bonds to or on the enzyme
tends to be toxic

10

uncompetitive inhibitors are molecules that

cannot be bound to the enzyme until the substrate has bonded itself on the enzyme
inhibitor only binds to an allosteric site

11

in uncompetitive inhibition, Km

decreases

12

in uncompetitive inhibition, Vmax

decreases

13

mixed-type inhibitors are molecules that

can bind to either the unoccupied enzyme or the enzyme-substrate complex

14

in mixed-type inhibition, Km

varies

15

in mixed-type inhibition, Vmax

decreases