Pyruvate Dehydrogenase Complex Flashcards Preview

MCAT biochemistry > Pyruvate Dehydrogenase Complex > Flashcards

Flashcards in Pyruvate Dehydrogenase Complex Deck (12):
1

PDC and the krebs cycle takes place in what part of the cell?

the matrix of the mitochondria

2

what transport protein takes pyruvate from the cytosol to the mito matrix?

pyruvate translocase

3

dehydrogenase in these terms means to

oxidized the pyruvate molecule (dehydrating/oxidative carboxylation)

4

the cofactor involved in this reaction is

coenzyme A

5

while pyruvate is being oxidized, what is being reduced?

NAD+ is reduced to NADH

6

during the oxidation of pyruvate a carbon molecule is lost thus what is produced?

carbon dioxide (CO2)

7

the pyruvate oxidation to acetyl CoA has a delta G of what and the reaction is

negative delta G and the reaction is irreversible

8

what are the two pathways of acetyl CoA once it is produced from the oxidization of pyruvate?

1) enters into the Krebs cycle for further production of ATP, NADH, and FADH2
2) used for fatty acid production when ATP levels are high thus not necessary to enter into Krebs cycle

9

what is the major regulator of which pathway acetyl CoA will take?

allosteric regulation

10

allosteric activators in this complex are

the reactants: CoA, NAD+, pyruvate
AMP and calcium

11

allosteric inhibitors in this complex are

products: acetyl CoA, NADH
ATP, fatty acids

12

molecular structure of acetyl CoA

C-C-S-CoA