Flashcards in Pyruvate Dehydrogenase Complex Deck (12):
PDC and the krebs cycle takes place in what part of the cell?
the matrix of the mitochondria
what transport protein takes pyruvate from the cytosol to the mito matrix?
dehydrogenase in these terms means to
oxidized the pyruvate molecule (dehydrating/oxidative carboxylation)
the cofactor involved in this reaction is
while pyruvate is being oxidized, what is being reduced?
NAD+ is reduced to NADH
during the oxidation of pyruvate a carbon molecule is lost thus what is produced?
carbon dioxide (CO2)
the pyruvate oxidation to acetyl CoA has a delta G of what and the reaction is
negative delta G and the reaction is irreversible
what are the two pathways of acetyl CoA once it is produced from the oxidization of pyruvate?
1) enters into the Krebs cycle for further production of ATP, NADH, and FADH2
2) used for fatty acid production when ATP levels are high thus not necessary to enter into Krebs cycle
what is the major regulator of which pathway acetyl CoA will take?
allosteric activators in this complex are
the reactants: CoA, NAD+, pyruvate
AMP and calcium
allosteric inhibitors in this complex are
products: acetyl CoA, NADH
ATP, fatty acids