Gluconeogenesis Flashcards Preview

MCAT biochemistry > Gluconeogenesis > Flashcards

Flashcards in Gluconeogenesis Deck (19):
1

gluconeogensis occurs in the

liver

2

in terms of glucose, there are two states the body can be in

fed or fasted

3

in the fed state, glucose

is directly broken up (glycolysis) and put into blood to be use in blood glucose level regulation

4

in fasted state, the first thing that can occur is when glycogen is

stored away in liver from the fed state to be broken down later for BGL regulation
this process can only last 10-18 hours

5

in fasted state, the second thing that can occur is when body forms glucose from

non-carbohydrate resources such as amino acids carbon skeletons, lactate, kreb cycle intermediates, pryuvate, etc so that they can be manipulated into glucose to be used to maintain BGL and contribute ATP

6

gluconeogensis is essentially the ____ of glycolysis

reverse

7

the body has to adjust for three reactions because in glycolysis

three of the reactions are unidirectional

8

the unidirectional reactions of glycolysis (the adjusted ones for gluconeogensis) are

reaction 1, reaction 3, and reaction 10

9

reaction 10 of glycolysis is the conversion of phosphoenolpyruvate to pyruvate using pyruvate kinase

in gluconeogensis, pyruvate is reacted with pyruvate carboxylase enzyme to yield oxaloacetate which is then reacted with PEP carboxykinase enzyme to produce PEP (phosphoenolpyruvate)

10

reaction 3 of glycolysis is the conversion of fructose-6-phosphate to fructose-1,6-biphosphate using phosphofructokinase

in gluconeogensis, FBP is reacted with fructose-1,6-bisphosphatase enzyme to yield F6P

11

reaction 1 of glycolysis is the conversion of glucose to glucose-6-phosphate using hexokinase

in gluconeogensis, glucose-6-phosphate is reacted with glucose-6-phosphotase to yield glucose

12

in the regulation of glycolysis and gluconeogensis, the fast (seconds) regulators are

le chatelier principle
allosteric inhibitors/activators

13

in the regulation of glycolysis and gluconeogensis, the slow regulators (hours/days) are

transcription (DNA to mRNA to enzymes)

14

in the regulation of glycolysis and gluconeogensis, the middle regulators are

hormonal

15

the hormonal regulators are

insulin and glucagon

16

when the BGL is increased, what is released?

insulin

17

when the BGL is decreased, what is released?

glucagon

18

insulin promotes

glycolysis to breakdown

19

glucagon promotes

gluconeogensis to build