EX 2; Blood and Hemostasis Flashcards Preview

AU14 Physiology > EX 2; Blood and Hemostasis > Flashcards

Flashcards in EX 2; Blood and Hemostasis Deck (19):
1

What are the totals of erythrocytes, leukocytes or platelets

erythrocytes; 5 million/cubic millimeter
leukocyte; 7000/cubic millimeter
platelets; 250000/cubic millimeter

2

What does the bi-concavity of the RBC do for the cell

high surface area-to-volume ratio for better diffusion of oxygen and CO2

3

What is the limiting factor in erthyropoiesis

iron

4

What is needed to protect from anemia

highly developed storage and recycling mechanisms of iron

5

This serves as a storage buffer for iron

ferritin

6

What is the lifespan of RBCs

~120 days
1% of all RBCs replaced daily
~250 million

7

This is the major breakdown product of hemoglobin

bilirubin

8

What happens to iron when it is released from destroyed RBCs

it is bound by transferrin and delivered to bone marrow

9

This is needed for thymine, if deficient, there is impaired cell division

folic acid

10

This is required for the action of folic acid, it requires an intrinsic factor and if there is no factor, then there is pernicious anemia

B12

11

How is erythropoeisis regulated

hormonally regulated

12

Decreased oxygen to the kidney causes what to occur

The secretion of erythropoeitin which activates receptors in bone marrow, leading to an increase in the rate of erythropoiesis

13

What are five causes of anemia

iron deficiency
bone marrow failure due to toxic drugs or cancer
blood loss
inadequate secretion of erythropoietin
excessive destruction of erythrocytes

14

What are three causes behind anemia

decrease the total number of erythrocytes
diminished concentration of hemoglobin
combination

15

This is a single amino acid genetic mutation in hemoglobin which distorts the RBC to form other shapes

Sickle cell anemia

16

This is the stoppage of bleeding

hemostasis

17

What are the two processes that accomplish hemostasis

formation of platelet plug
blood coagulation (clotting)

18

This component is critical for hemostasis

platelets

19

This is an anti-coagulate

heparin