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2nd Shifting PHA6133 LAB > Ex. 3 - Hand Sanitizing Gels > Flashcards

Ex. 3 - Hand Sanitizing Gels Flashcards

(56 cards)

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1
Q

Hand sanitizers are applied to _______ (dry/wet) hands followed by rubbing

A

dry

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2
Q

These are used to remove microorganisms from the hands with the intent of preventing infections and reducing the spread of infectious diseases.

A

Hand sanitizers

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3
Q

Deliver an immediate benefit but provide no residual activity and contains either ethanol or isopropyl alcohol

A

Alcohol-based

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4
Q

Alcohol-based formulations contain at least ____(%) alcohol

A

62%

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5
Q

Alcohol-based formulations are most effective at ___ - ___(%)

A

60-95%

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6
Q

Alcohol-based, supplemented have antimicrobial agents that provide more persistent activity, delaying the reestablishment of _________________

A

transient microbiota

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7
Q

Alcohol-based, supplemented contains ____(%) alcohol plus antimicrobial agent

A

62%

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8
Q

These are alcohol-free, contains water, surfactant, and antimicrobial ingredients such as benzalkonium chloride and triclosan

A

Water-based

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9
Q

Water-based formulations must take into consideration the ____________ of antimicrobial active

A

bioavailability

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10
Q

Water-based formulations have the advantage of no ____________

A

drying effect

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11
Q

the difference between FORMULATION 1 and FORMULATION 2 in the WHO-recommended Handrub Formulations

A

Difference in supplemented alcohol. Formulation 1 uses Ethanol 96% (80% v/v), while Formulation 2 uses Isopropyl alcohol 99.8% (75% v/v)

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12
Q

A dispersion system composed of small or large molecules dispersed throughout a liquid vehicle

A

Gels

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13
Q

Gels can be classified based on:

A

Colloidal phases, nature of solvent used, physical nature, and rheological properties

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14
Q

single- or two-phase system

A

Colloidal phases

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15
Q

hydrogel or organogel, xerogel

A

Nature of solvent used

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16
Q

plastic, pseudoplastic, or thixotropic

A

rheological properties

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17
Q

are also referred to as shear-thinning fluids. The viscosity of these fluids will increase with increasing shear rate.

A

pseudoplastic

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18
Q

having a viscosity that decreases when a stress is applied, as when stirred

A

thixotropic

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19
Q

Ingredients Generally Recognized As Safe and Effective (GRASE) for claimed therapeutic indication. Can be used in formulations, documented to be safe

A

Category I

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20
Q

Ingredients generally not recognized as safe and effective or have unaccepted indications (not GRASE). Cannot be included in a formulation

A

Category II

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21
Q

Insufficient data available to permit final classification. Can be used in formulations, however, it is monitored by post-marketing surveillance. It will be removed if it is documented to be harmful

A

Category III

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22
Q

Antimicrobial agents for alcohol-based formulations

A

Ethanol, isopropyl alcohol, n-propanol, hydrogen peroxide

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23
Q

Antimicrobial agents for water-based formulations

Study These Flashcards
A

Benzalkonium chloride, triclosan

24
Q

Synthetic polymers

Study These Flashcards
A

Carbomers, polyacrylates, poloxamer, polyvinyl alcohol

25
Natural polymers
Carrageenan, chitosan, collagen, guar gum, xanthan gum, dextran, cellulose derivatives
26
Also known as thickening agents. Used to enhance the viscosity of the product and stabilizers
Gelling agents
27
Gelling agents are added in concentrations mostly less than ____(%) (usually 0.3%-2%)
10%
28
Semi-synthetic polymers
Cellulose derivatives: Carboxymethyl Cellulose, Hydroxypropyl Methylcellulose, Ethyl Cellulose, Hydroxyethyl Cellulose, Hydroxypropyl Cellulose, Methyl Cellulose, Sodium Alginate
29
Added to reduce dryness brought by alcohol in alcohol-based formulation. Retains natural moisture of the skin
Skin conditioning agents
30
Examples of skin conditioning agents
Aloe vera, glycerin, propylene glycol, isopropyl myristate, vitamin E
31
To avoid skin irritation
pH modifying agent
32
For water-based formulation, a ____ (high/low) pH matrix is used
low
33
pH modifying agent examples
Citric acid, triethanolamine
34
the gelling function of carbomer is observed when it is paired with ________
triethanolamine
35
For aesthetic and product identification purposes and consumer acceptance only.
Fragrance and colorants
36
In using fragrance and colorants, consideration on __________ is important
allergic reactions
37
T/F: The colorant should not stay on the skin, this is why they shouldn't be water soluble
False. Should be water soluble
38
Use of 70% alcohol (ethanol)
antiseptic
39
use of Carbomer 980
gelling agent
40
use of glycerin in the formulation
emollient
41
Use of 0.15% Aminomethyl propanol
pH adjuster (Qs to pH 4)
42
Use of deionized water
Vehicle
43
Packaging for Hand Sanitizing Gels
Plastic bottles * Screw top * Disc top * Flip-flop cap * Pumphead
44
Disperse Carbomer 980 onto rapidly agitated ethanol. This should be done _______ (quickly/slowly) to hasten the dispersion process.
slowly
45
Product evaluation for antimicrobial activity
In vitro and In vivo
46
In vitro tests
* Determination of MIC * Time-kill studies
47
In vivo test for E. coli
Bactericidal Test (EN 1500)
48
Fingerpad method for viruses
ASTM E-1838
49
Fingerpad method for bacteria
ASTM E-2276
50
Fingerpad method for fungi
ASTM E-2613
51
Whole hand method for viruses
ASTM E-2011
52
Safety parameters for hand sanitizing gels
* Alcohol content * Methanol and 1-propanol content
53
Quality Parameters
* Organoleptic Properties * Rheologic Properties * Spreadability * Extrudability * pH * Specific gravity * Moisture (water) content * Preservative efficacy
54
T/F: gel should be translucent when it comes to its organoleptic properties
True
55
The "squeezability" of the product, which inspects both the product and container
Extrudability
56
Bonus question: Who has the cleanest, softest, and prettiest hands?
Andre Martin E. Marapao

2nd Shifting PHA6133 LAB (4 decks)

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