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PHM 701 > Exam 2 > Flashcards

Exam 2 Flashcards

1
Q

Mood stabilizer good for Manic

A

Lithium
VPA
SGA

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2
Q

Can get ECT with manic when on

A

Li + AED + AED
or
Li + APS + AED

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3
Q

First line hypomania

A

Li or VPA or SGA or carbamazepine

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4
Q

Mood stabilizers good for depression

A

Lithium, quetiapine, lurasidone

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5
Q

After optimized mood stabilizer / adding what can be done in depressive episode

A

Add carbamazepine or anti depressant

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6
Q

Others you can consider in depression

A

Olanzapine/Fluoxetine
Lamotrigine
Valproate

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7
Q

Need to be on what in depressive state to get ECT

A

Li +Lamotrigine + AD
or
Li + Quetiapine + AD

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8
Q

Manic general drugs

A

1st line lithium
carba (or Ox)
SGAs + Halo + chloro
Benzo (loraz, clonaz if needed)

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9
Q

Mixed in general

A

Divalproex sodium

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10
Q

Maintenance general

A

1st line Lithium
Can do divalproex sodium
Lamotrigine (good to prevent depression)
Aripiprazole, olanzapine, asenapine, risperidone,
LAI Halo + Fluphen

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11
Q

Depression general

A

2nd line Lithium in BP II
Quetiapine, Lurasidone, Olanzapine/Fluoxetine, carbamazepine

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12
Q

GAD 1st line

A

Escitalopram
Paroxetine
Sertraline

Duloxetine
Venlafaxine XR

Pregabalin

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13
Q

GAD 1st line FDA approved

A

Escitalopram
Paroxetine

Duloxetine
Venlafaxine ER

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14
Q

GAD 2nd line FDA approved

A

Buspirione

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15
Q

Panic disorder 1st line

A

Citalopram
Escitalopram
Fluoxetine
Fluvoxamine
Paroxetine
Sertraline

Venlafaxine XR

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16
Q

Panic disorder 1st line FDA approved

A

Fluoxetine
Paroxetine
Sertraline

Venlafaxine XR

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17
Q

SAD 1st line

A

Escitalopram
Fluvoxamine
Paroxetine
Sertraline
Venlafaxine
Pregabalin

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18
Q

SAD 1st line FDA approved

A

Paroxetine
Sertraline
Venlafaxine XR

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19
Q

PTSD 1st line

A

Fluoxetine
Paroxetine
Sertraline
Venlafaxine

20
Q

PTSD 1st line FDA approved

A

Paroxetine
Sertraline

21
Q

OCD 1st line

A

Citalopram
Escitalopram
Fluoxetine
Fluvoxamine
Paroxetine
Sertraline
Clomipramine

22
Q

OCD 1st line FDA approved

A

Fluoxetine
Fluvoxamine
Paroxetine
Sertraline

23
Q

Sinemet

A

Carbidopa/Levodopa

24
Q

Minimum carbidopa dose

A

70-100mg QD

25
Q

Stalveo

A

Carbidopa/Levodopa/Entacapone

26
Q

COMT inhibitors

A

Entacapone
Tolcapone

27
Q

Entacapone dose

A

200 with each Carbidopa/Levodopa dose

28
Q

Levodopa starting dose

A

200-300mg in divide doses

29
Q

Carbidopa/Levodopa ratio of dose

A

1:4

30
Q

Inbrija

A

inhaled levodopa

31
Q

MAOi-Bs

A

Selegiline
Rasagiline
Safinamide

32
Q

Ergots

A

Bromocriptine
Pergolide
Cabergoline

33
Q

Wearing off effect - solution

A

increase frequency
add MAOi
add COMT

34
Q

Off, no on - solution

A

take on empty stomach, ODT, APO SQ

35
Q

Delayed onset - solution

A

take on empty stomach, water, avoid protein
Get some IR

36
Q

Peak effect dyskinesia

A

Decrease dose
switch to CR

37
Q

drug induced psychosis get rid of

A

anti cholinergic
D/c taper amantadine
Selegiline
taper and D/c DA
decrease dopa end of day dose and d/c COMT

Add SGAs
Quetiapine
clozapine
Pimavanserin

38
Q

Hallmarks of dementia

A

beta amyloid plaques and neurofibrillary tangles

39
Q

Hippocampus

A

short term to long term

40
Q

Hypothalamus

A

monitors certain activities and controls body’s internal clock

41
Q

Thalamus

A

sensory and limbic information to send to cerebral cortex

42
Q

Limbic system

A

controls emotions and instinctive behavior

43
Q

Approved drugs for dementia

A

Donepezil
Rivastigmine
Galantamine
Memantine

44
Q

Namzaric

A

Memantine + Donepezil

45
Q

Targets for new Alzheimer’s drugs

A

Block B-secretase
block gamma secretase
Increase A-secreatase to out compete B
Increase likelihood of APP processing by A-secreatase
Immunization
enhance proteolytic degradation

PHM 701 (7 decks)

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