Flashcards in Exam 2 Antifungals Deck (11):
5 reasons a patient may develop an upset in the oral flora balance resulting in a fungal infection
2. Systemic disease
6 clinical appearance of oral fungal infections
1. "cottage-cheese" appearance
3. Atrophic tongue
5. Geographic tongue
6. ANGULAR CHEILITIS
Systemic treatment for a fungal infection is used with caution due to its toxicities, drug interactions, hard on the liver, and it promotes resistance. When is it acceptable to use a systemic treatment?
Chronic, extensive/severe mucocutaneous candidiasis and the very immunocompromised.
2 types of systemic treatment for a fungal infection
1. AZOLE antifungals
2. amphotericin - IV for HIV patients
2 types of azole antifungals
1. itraconazole (Sporanox) - severe cardio/neuropathy effects
2. fluconazole (diflucan)
Why is topical treatment of antifungals preferred? What is a drawback of topical treatment?
Lower compliance - usually needed to apply 4-5x/day
What are the 2 go to topical topical medications?
1. NYSTATIN (MYCOSTATIN)
2. clotrimazole - when nystatin is not effective (hard on liver)
When treating angular cheilitis,, combination drugs are used, what are they?
Antifungal and topical steroid
1. iodoquinol and hydrocortisone cream
2. nystatin and triamcinolone acetonide ointment
What are the 4 forms of antifungal agents?
2. Troches - sweetened vaginal preps with cocoa butter
3. Pastilles - lozenge
How does nystatin work?
Similar to penicillin, it binds to sterols in cell membrane, changes permeability which causes lysis and cell death