Exam 2 Antihistamines Flashcards Preview

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Flashcards in Exam 2 Antihistamines Deck (13):
1

What 4 affects does histamine have on the cardiovascular system?

1. Drop in BP
2. Tachycardia
3. Reddening of skin
4. Throbbing headache

2

What are 2 respiratory system effects of histamine?

1. Constricts respiratory smooth muscle
2. Secretion of fluid and prostaglandin formation

3

What 3 things does histamine affect in the GI tract?

1. Secretion of HCL
2. Contraction of ileum
3. Increased salivary secretions

4

What effects do H1 antihistamines have on the body?

1. Produces CNS depression (sleepiness)
2. Treat motion sickness
3. Block constriction of respiratory smooth muscle
4. Blocks flare (wheals) and itch

5

What is the main role of H2 antihistamines?

Inhibits HCL release from parietal cells

6

4 popular H2 antihistamines

1. cimetidine (Tagamet)
2. famotidine (pepcid)
3. nizatidine (Axid)
4. ranitidine (Zantac)

7

If H2 is added to H1 blockers, it blocks all ____ effects of histamine

Cardiovascular

8

What are 4 clinical uses for H2 antihistamine?

1. Peptic ulcer
2. Hypersecretion of gastric acid
3. GERD
4. Zollinger-Ellison Syndrome

9

4 common side effects of antihistamines

1. Sleepiness/drowsiness
2. Xerostomia
3. Dry mucous membranes
4. Older antihistamines caused ventricular arrhythmias (non-sedating)

10

Name 4 clinical uses of H1 antihistamines and 5 "off label" uses

1. allergic rhinitis
2. pollinosis
3. urticaria (localized edema with wheals)
4. anaphylaxis

5. motion sickness
6. nausea/vomiting
7. dizziness
8. sleep aid
9. local anesthetics

11

Name 3 sedating antihistamines

1. diphenhydramine (Benadryl) - Ethanolamines
2. chlorpheniramine (Chlor-Trimenton) - Alkylamines
3. cetirizine (Zyrtec)

12

Name 3 non-sedating antihistamine. They have longer half life so only 1 pill per day but they take a long time to kick in plus they can cause headaches

1. Ioratadine (Claritin)
2. fexofenadine (Allegra)
3. desloratadine (Clarinex)

13

What is the safest/most recommended GI antihistamine drug in this class? (fewest drug interactions)

ranitidine (Zantac)