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Immuno > Exam 3 Class Review Questions > Flashcards

Exam 3 Class Review Questions Flashcards

1
Q

Pernicious anemia is caused by deficiency of what?

A

B12

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2
Q

Name the 3 pathways for T cell tolerance.

A

1: Clonal abortion
2: Functional deletion
3: T cell suppression

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3
Q

Is Lupus more frequent in men or women?

A

Women

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4
Q

Type 2 diabetes and latent adult diabetes are the same. True or false?

A

False

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5
Q

Low TSH, elevated Free T4 is associated with what disease?

A

Graves disease

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6
Q

BJ proteins are soluble and insoluble at what temperatures?

A

Precipitate at 60 and Dissolve at 100

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7
Q

Tolerance is a lack of response to what?

A

Self antigens

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8
Q

AIH (Autoimmune hepatitis) is more common in males or females?

A

Females

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9
Q

Discoid lupus is always limited to what?

A

Skin

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10
Q

What is most common form of MS?

A

Progressive Relapsing

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11
Q

What are the 2 types of syndromes you see bence jones proteins in?

A

Typical Monoclonal Gammopathy
Free light chain disease

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12
Q

Which autoimmune disorder is produced by T cells/Antibodies against antigens isolated to a single organ?

A

Organ specific disorders

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13
Q

In MM, what percent of patients have broadly disseminated destruction of the skeleton?

A

90%

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14
Q

What are the two most frequent causes of death in SLE?

A

Renal Failure and Chronic Infectious disease

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15
Q

What is the most frequent cause of death for those w/RA?

A

Cardiovascular disease

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16
Q

Which is not 1 of the 4 pathways of B cell tolerance?

Clonal exhaustion
Functional deletion
Clonal deletion
Clonal abortion

A

Clonal Deletion

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17
Q

What IG classes are associated with Rheumatoid Factor?

A

IgA, IgG, and IgM

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18
Q

% of patients who take hydra…………..

A

4%

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19
Q

Citrullination is the process of proteins being altered during inflammation. T or F?

A

True

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20
Q

T/F: RF testing is more sensitive than cyclic citrullinated peptide (CCP)

A

False

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21
Q

What is the most common heavy chain disease?

A

Alpha Heavy Chain

22
Q

List 3 factors that influence the development of autoimmune disorders

A

Genetic predisposition
Environmental
Patient Age

23
Q

What are 4 pathways of B cell tolerance?

A

Clonal abortion
Functional deletion
clonal exhaustion
Antibody forming cell blockade

24
Q

What stage of autoimmune disease is associated w/active disease state?

A

Propagation

25
Q

As a B cell matures, it becomes more susceptible to tolerization. True or false?

A

False, becomes less susceptible

26
Q

RA is a multisystem autoimmune disorder. True or false?

A

True

27
Q

Which cytokine is essential for survival and growth of myeloma cells?

A

IL-6

28
Q

In SLE, what renal disease progression is unpredictable?

A

glomerulonephritis

29
Q

Lupus is 5-10 times more frequent in women than men. True or false?

A

False, 10-15 times

30
Q

Immunoelectrophoresis determines blood levels of what Igs?

A

IgGAM

31
Q

What is the first Ig tested to identify celiac?

A

IgA

32
Q

FISH testing stands for?

A

Fluorescent in situ hybridization

33
Q

Postmenopausal women that begin estrogen therapy are more likely to develop lupus. True or False?

A

True

34
Q

RF is associated with what 3 Igs?

A

IgM, IgA, IgG

35
Q

4 different forms of lupus…?

A

SLE
Discoid
Drug induced
Neonatal

36
Q

Which cell types are involved in pathogenesis of SLE?

A

T cells, B cells, Dendritic cells

37
Q

What is the most common Antibody in MM?

A

IgG

38
Q

Which type of antibodies are the only autoantibodies that may be used to monitor SLE?

A

Anti-dsDNA

39
Q

What causes renal issues in SLE?

A

Buildup of immune complexes in the glomerulus

40
Q

What is the unique characteristic of BJ proteins in regard to heating?

A

Soluble at room temp, precipitates 60-70 degrees and dissolves at 100 degrees

41
Q

What % of patients are diagnosed w/ MM without symptoms?

A

20%

42
Q

Non-classified group of autoimmune hemolytic anemia?

A

paroxysomal cold hemoglobinuria and atypical AIHA

43
Q

MM has an increase in CD4 cells and decrease in CD8 cells. True or false?

A

False

44
Q

Which is an important biological marker for MM?
ESR
CRP
Carcinoembryonic antigen
BJ proteins

A

BJ proteins

45
Q

Bone pain is a common symptom of Waldenstrom Macroglobulinemia. True or false?

A

False

46
Q

MM requires _________ bone marrow plasma cells for diagnostic criteria.

A

Greater than 10%

47
Q

What exogenous factors may influence development of autoimmunity?

A

UV, drugs, infectious diseases, chronic infections, viral infections

48
Q

SLE affects the joints, connective tissues, and what other system?

A

Collagen system

49
Q

MM is the most common form of dysproteinemia. True or false?

A

True

50
Q

Which of the following are factors associated with RA:

Genetic
Hormonal
Environmental

A

Genetic and hormonal

51
Q

What are the sequential stages of autoimmune disease?

A
  1. Initiation
  2. Propagation
  3. Resolution

Immuno (23 decks)

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