Exam 3: Hematopoiesis Flashcards Preview

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Flashcards in Exam 3: Hematopoiesis Deck (12):
1

Describe Hematopoietic Stem Cells:

 

  • Pluripotential
  • Self-renew
  • Produce two precursor cellls
    • myeloid stem cells
    • lymphoid stem cells
  • can only identify by cell surface markers

2

Leukocytes can be divided further give the two major divisions:

  1. Granulocytes
  2. Agranulocytes

3

Ganulocytes, a form of Leukocyte, has three additonal linages, name them.

  • Neutrophils
  • basophils
  • eosinophils

4

Agranulocytes, a form of leukocytes has two additional linages, what are they?

  • Monocytes
  • Lymphocytes

5

Myeloid stem cells, derived from hematopoietic stem cells can give rise to 5 CFU, what are they?

 

  • Erthrooid
  • Megakaryocyte
  • Basophil
  • Eosinophil
  • Granulolcyte-Macrophage

6

What two cell lines can arise from lymphoid stem cells?

 

  • T-cell progenitor
    • matures in thymus
  • B-cell progenitor
    • matures in bone marrow

7

A GM-CFU can give rise to two different linages, explain the steps to get to a macrophage. 4 Steps:

  1. Monoblast
  2. promonocyte
  3. monocyte
  4. macrophage

8

A GM-CFU can give rise to two different linages, explain the steps to get to a Neutrophil. 6 Steps

  1. Myeloblast
  2. Promyelocyte
  3. meylocyte
  4. Metamyelocyte
  5. band cell
  6. Neutrophil

9

An Eosininophil/basophil-CFU can give linages, explain the steps to get to a Eosiniphil or Basophil. 6 steps

 

  1. Myeloblast
  2. Promyelocyte
  3. Myelocyte
  4. metamyelocyte
  5. band cell
  6. eosinophil or basophil (becomes mast cell)

10

A megakaryocyte CFU will give rise to a platelet, what 3 steps are involved?

 

  1. Megakaryoblast
  2. megakaryocyte
  3. platelets

11

The Erythoroid CFU will eventually give rise to RBCs, what steps are required to get there? 6 steps

 

  1. Proerythroblast
  2. Basophilic erythroblast
  3. polychromatophilic erythroblast
  4. orthochromatic erythroblast
  5. Reticulocyte
  6. Erythrocyte (RBC)

12

Explain Erythropoietin and the JAK-STAT Pathway

 

  1. EPO produced in renal cortex transported to bone marrow by blood circulation
  2. In bone marrow EPO binds to dimerized EPO receptor and induces bind of STAT5 protein to JAK2
  3. STAT5 becomes activated (phophorylated) and homodimerizes.
  4. the phosphorylated STAT5 homodimer translocates into the nucleus
  5. binds to DNA and activates transcription of specific genes required for erythopoiesis.