Exam 4: Immune lymphatic system Flashcards Preview

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Flashcards in Exam 4: Immune lymphatic system Deck (15):

Innate immunity

Lacks specificity and memory. Response= inflammation. Neutrophils are first responders.


Acquired immunity

response to antigens, more powerful than innate, longer to develop, ***Specificity and memory***


What are the 3 types of lymphocytes?

B cells (bone marrow), T-cell (thymus), NK Cells.


What are 3 types of accessory cells or APCs?

Monocyte derive: macrophages and dendritic cells. Lymph node-derived: Follicular dendritic cells.


adaptive/acquired immunity has two ways to acquire immunity:

1. Humoral: Antibody-mediated, plasma cells.
2. Cell-mediated immunity: (T & B cells and APCs)


Where did the immunity of passive immunity arise from?

Active immunity?

1. antibodies from mom across placenta
2. antibodies of immunized animals
3. antitoxins (diptheria)

Active immunity came from T-cell (post disease)


Define lymphoid tissue

appears in the body as a gradient from diffuse lymphoid tissue to aggregated lymphoid tissue to lymphoid organs.


What are the primary and secondary lymphoid organs?

primary: thymus and bone marrow
Secondary: lymph nodes, spleen, tonsils
- lymphocytes originate in primary and then reside in secondary.


T/F Mature B cells binding less strongly to a SELF-ANTIGEN survive and enter blood circulation?



Describe lymphopoiesis

all immune system cells originate in bone marrow. Immature T cells travel to thymus and B-cells travel to specific regions in lymphoid tissue.


Lymphoid stem cells generate B and T lymphocytes. Name the two T-cell lines and 3 b-cell lines

T cell Precursor ---> T-cell
B-cell precursor ---> B-cell ---> plasma cell


5 classes of Immunoglobulins (Anitbodies)

MADGE IgM, IgA, IgD, IgG, IgE.


Immunoglobulins have light and heavy chains. What doe the highly variable and less variable regions contain/do?

Highly variable regions: Fab fragment, recognizes antigen
Less variable regions: Fc Fragment, Binds antibody to cells.


Characteristics of MADGE

M: 1st antibody class expressed by developing b-cells
A: saliva, milk, GU and respiratory tracts
D: On surface of B cells traveling to lymphoid organs
G: Major Ig in blood, most antibody activity (cross placenta)
E: Associated with allergic responses


Maturation of B cells involves the appearance of:

IgM & IgD & MHC II ( ForCe complement II B an MD)
Ig Fc receptors