Flashcards in Exam 4: Immune lymphatic system Deck (15):
Lacks specificity and memory. Response= inflammation. Neutrophils are first responders.
response to antigens, more powerful than innate, longer to develop, ***Specificity and memory***
What are the 3 types of lymphocytes?
B cells (bone marrow), T-cell (thymus), NK Cells.
What are 3 types of accessory cells or APCs?
Monocyte derive: macrophages and dendritic cells. Lymph node-derived: Follicular dendritic cells.
adaptive/acquired immunity has two ways to acquire immunity:
1. Humoral: Antibody-mediated, plasma cells.
2. Cell-mediated immunity: (T & B cells and APCs)
Where did the immunity of passive immunity arise from?
1. antibodies from mom across placenta
2. antibodies of immunized animals
3. antitoxins (diptheria)
Active immunity came from T-cell (post disease)
Define lymphoid tissue
appears in the body as a gradient from diffuse lymphoid tissue to aggregated lymphoid tissue to lymphoid organs.
What are the primary and secondary lymphoid organs?
primary: thymus and bone marrow
Secondary: lymph nodes, spleen, tonsils
- lymphocytes originate in primary and then reside in secondary.
T/F Mature B cells binding less strongly to a SELF-ANTIGEN survive and enter blood circulation?
all immune system cells originate in bone marrow. Immature T cells travel to thymus and B-cells travel to specific regions in lymphoid tissue.
Lymphoid stem cells generate B and T lymphocytes. Name the two T-cell lines and 3 b-cell lines
T cell Precursor ---> T-cell
B-cell precursor ---> B-cell ---> plasma cell
5 classes of Immunoglobulins (Anitbodies)
MADGE IgM, IgA, IgD, IgG, IgE.
Immunoglobulins have light and heavy chains. What doe the highly variable and less variable regions contain/do?
Highly variable regions: Fab fragment, recognizes antigen
Less variable regions: Fc Fragment, Binds antibody to cells.
Characteristics of MADGE
M: 1st antibody class expressed by developing b-cells
A: saliva, milk, GU and respiratory tracts
D: On surface of B cells traveling to lymphoid organs
G: Major Ig in blood, most antibody activity (cross placenta)
E: Associated with allergic responses