Exam 4: Immune lymphatic system Flashcards Preview

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Flashcards in Exam 4: Immune lymphatic system Deck (15):
1

Innate immunity

Lacks specificity and memory. Response= inflammation. Neutrophils are first responders.

2

Acquired immunity

response to antigens, more powerful than innate, longer to develop, ***Specificity and memory***

3

What are the 3 types of lymphocytes?

B cells (bone marrow), T-cell (thymus), NK Cells.

4

What are 3 types of accessory cells or APCs?

Monocyte derive: macrophages and dendritic cells. Lymph node-derived: Follicular dendritic cells.

5

adaptive/acquired immunity has two ways to acquire immunity:

1. Humoral: Antibody-mediated, plasma cells.
2. Cell-mediated immunity: (T & B cells and APCs)

6

Where did the immunity of passive immunity arise from?

Active immunity?

1. antibodies from mom across placenta
2. antibodies of immunized animals
3. antitoxins (diptheria)

Active immunity came from T-cell (post disease)

7

Define lymphoid tissue

appears in the body as a gradient from diffuse lymphoid tissue to aggregated lymphoid tissue to lymphoid organs.

8

What are the primary and secondary lymphoid organs?

primary: thymus and bone marrow
Secondary: lymph nodes, spleen, tonsils
- lymphocytes originate in primary and then reside in secondary.

9

T/F Mature B cells binding less strongly to a SELF-ANTIGEN survive and enter blood circulation?

True

10

Describe lymphopoiesis

all immune system cells originate in bone marrow. Immature T cells travel to thymus and B-cells travel to specific regions in lymphoid tissue.

11

Lymphoid stem cells generate B and T lymphocytes. Name the two T-cell lines and 3 b-cell lines

T cell Precursor ---> T-cell
B-cell precursor ---> B-cell ---> plasma cell

12

5 classes of Immunoglobulins (Anitbodies)

MADGE IgM, IgA, IgD, IgG, IgE.

13

Immunoglobulins have light and heavy chains. What doe the highly variable and less variable regions contain/do?

Highly variable regions: Fab fragment, recognizes antigen
Less variable regions: Fc Fragment, Binds antibody to cells.

14

Characteristics of MADGE

M: 1st antibody class expressed by developing b-cells
A: saliva, milk, GU and respiratory tracts
D: On surface of B cells traveling to lymphoid organs
G: Major Ig in blood, most antibody activity (cross placenta)
E: Associated with allergic responses

15

Maturation of B cells involves the appearance of:

IgM & IgD & MHC II ( ForCe complement II B an MD)
Complement
Ig Fc receptors