Exam 3: Lecture 8

Question 1

Primary Osteoarthritis

Answer 1

Cause is unknown.

Question 2

Osteoarthritis

Answer 2

Likely initiated by mechanical forces and leads to increased breakdown of cartilage

Question 3

Secondary Osteo

Answer 3

Micro injury to bone

Decreased in chondrocytes repair abilities

Question 4

Why is OA not considered an inflammatory disease

Answer 4

Mild swelling but not main component of disease

Question 5

Clinical representation of OA

Answer 5

Degenerative and onset of 40
symptoms pain, stiffness and swelling
Slowly progressive

Question 6

OA affects which joints?

Answer 6

Cervical or lumbar spine
CMP 
PIP
DIP
Hip 
Knee
Subtalar joint
1st metarsophalengeal

Question 7

Joints that are uncommon for RA to affect

Answer 7

shoulder, wrist, elbow

Question 8

Herberden’s nodes

Answer 8

size of peas and on dip’s

Question 9

Bouchards nodes

Answer 9

develop on pip and often enlarge joints

Question 10

OA vs. RA

Answer 10

OA: non systemic, noninflammory, and localized pathology
RA: systemic, inflammatory that involves multiple joints and possible organs

Question 11

Classification of RA

Answer 11

Class 1: normal
Class 2:
Class 3:
Class 4: limited ability

Question 12

Classification of Progressive RA

Answer 12

Stage 1: no presentation of x-ray
Stage 2: slight changes, no joint deformity
Stage 3: joint deformity
Stage 4: joints fused

Question 13

Example of some inflammatory dieseases

Answer 13

RA
SLE- lupus
Scleroderma
Vasculitis

Question 14

Some RA variants

Answer 14

Felty syndrome

Still disease: juvenile, fever

Question 15

Management

Answer 15

through multi-disciplinary approach.

Medications

Question 16

Group 1 of Meds

Answer 16

Non steroidal anti-inflammatory drugs (NSAID)

ex. ibuprofen

Question 17

Group 2 of Meds

Answer 17

anti-rheumatic drugs- slow or halt progression of disease

ex. gold compounds

Question 18

Group 3 of Meds

Answer 18

Cortico-steriods- relieve inflammation

ex. cortisone

Question 19

Group 4 Meds

Answer 19

Biological response modifiers- inhibit progression and relieve symptoms
ex. enbrel and remicade

Question 20

Non-drug approaches

Answer 20

Natural treatments
Remedies
Gluten

Question 21

Exercise Interventions for OA

Answer 21

decrease pain and inflammation,

performance in functional tasks

Question 22

Interventions for RA

Answer 22

same as OA plus taught to recognize symptoms, and modify activity

Question 23

Spondyloarthropathies

Answer 23

AS
Reactive arthritis
juvenile spondyloarthropathy

Question 24

Ankylosing Spondylitis

Answer 24

3 criterias
low back pain for longer 3 months
limitation of motion in lumbar spine
inflammation of eyes or compression of spinal cord ie. affects bowels

Question 25

AS

Answer 25

chronic inflammatory diesase Young adults 20-30 association with antigen HLA-B27

Question 26

Treatment for AS

Answer 26

reduce inflammatory Mackenzie exercises focus on extension and reduce flexion

Question 27

Uveitis

Answer 27

inflammation of uveal tract pain and redness visual loss or changes such as 'floaters'

Question 28

Non-inflammatory diesease

Answer 28

fibromyalgia | Chronic fatigue

Question 29

Fibromyalgia

Answer 29

muscular pain throughout body, classic tender spots More likely in women Emotional, physical trauma trigger

Question 30

Symptoms and criteria

Answer 30

fatigue, headaches, joint discomfort, muscle spasms. | wide spread pain for 3 months and 11/18 tender points

Question 31

Treatment for fibromyalgia

Answer 31

light aerobic exercises, stretching, improved sleep | focus on core and neck

Question 32

Chronic fatigue syndrome

Answer 32

unknown cause, sleep doesnt help this. Commonly 30-50 headaches, flu- like feeling and low grade fever. Anti-depressants used to treat

Question 33

Reactive arthritis

Answer 33

bacteria infection and peripheral arthritis with diarrhea

Question 34

local enthesopathy

Answer 34

inflammation of tendinous insertion to bone | Ulcers and roughened thickened skin

Question 35

Psoriatic

Answer 35

effect on DIP- swelling and deformity | related to scrolititis

Question 36

Gout

Answer 36

deposition of uric acid crystals in joints. | could be due to alcohol abuse, obesity, age etc

Question 37

Lupus

Answer 37

systematic, fever, fatigue, weight loss. | present in young women with redness of skin, enlarged liver/ spleen and easily bruised

Question 38

Scleroderma

Answer 38

disease that affects skin. Collagen disorder. | clinical features- skin ulcers, hands and mouse face

Question 39

What is the first symptom of scleroderma

Answer 39

hand swelling

Question 40

Vasulitides

Answer 40

inflammation of blood vessels Large areas of bruising fever

Question 41

treatments of vasulitides

Answer 41

blood transfusions and meds

Question 42

Takaysu's

Answer 42

pulseless disease affects 4-64 and 80% female

Question 43

Gaint cell

Answer 43

primary vessels in temporal region

Question 44

Sign of positive RA factor

Answer 44

HLA B27

Question 45

AS presents first on which joint/

Answer 45

Sacral- iliac joint