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Chem I > Exam 3 Review Questions > Flashcards

Exam 3 Review Questions Flashcards

1
Q

Which of the following statements is not true concerning testing for drugs of abuse?

a) A two-tired testing approach includes screening and confirmatory testing

b) Confirmatory testing must use methods with high specificity and low sensitivity

c) Screening tests detect classes of drugs

d) GC-MS is the reference method used for confirmation

A

Confirmatory testing must use methods with high specificity and low sensitivity

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2
Q

T/F:
Common routes of exposure to toxins are through the gastrointestinal tract, lungs, and skin.

A

TRUE

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3
Q

Which of the following is not true concerning analysis of toxic agents?
Correct answer:

a) Screening tests have good specificity but lack sensitivity

b) Confirmatory tests report the concentration of the analyte

c) Screening tests are a rapid test intended to detect the presence of a substance

d) The reference method for most compounds is gas chromatography with a mass spectrometer (GC-MS_

A

Screening tests have good specificity but lack sensitivity

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4
Q

Toxic levels of acetaminophen are associated with

A

Hepatotoxicity

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5
Q

Pharmacokinetics and drug concentration are influenced by which of the following factors?

A

Absorption, distribution, excretion, metabolism

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6
Q

A drug’s most direct and effective method of delivery to its site of action is:

A

Intravenous administration

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7
Q

A blood draw to determine a peak level of a drug should be drawn:

A

One hour after an orally administered dose

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8
Q

T/F:
Cytochrome P450 is an enzyme that influences the effectiveness of a drug in an individual.

A

TRUE

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9
Q

Tumor marker methodology include all of the following except:

a) Immunoassays

b) Gas chromatography

c) Immunohistochemistry

d) Enzyme analysis

A

Gas chromatography

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10
Q

Which of the following tumor markers is classified as an oncofetal antigen?
Correct answer:

a) Carcinoembryonic antigen (CEA)

b) CA 19-9

c) BRCA-1

d) hCG

A

Carcinoembryonic antigen (CEA)

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11
Q

Which tumor marker is associated with neuroblastoma?

a) CA-15-3

b) Carcinoembryonic antigen (CEA)

c) CA 125

d) Homovanillic acid (HVA)

A

Homovanillic acid (HVA)

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12
Q

T/F:
Abnormally low tumor marker concentrations are associated with antigen deficiency and can cause false negative results

A

FALSE

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13
Q

What is the major transporter of drugs

A

Albumin

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14
Q

The phenomenon in which a drug is metabolized and results in a reduced concentration of the drug before reaching the circulatory system

A

First Pass Effect

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15
Q

The study of the biochemical and physiological effects of drugs and their mechanisms of actions:

A

Pharmacodynamics

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16
Q

This tumor marker is often measured in both total and free form

A

PSA

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17
Q

The concentration range of a drug within which the drug produces the desired effect

A

Therapeutic range

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18
Q

This tumor marker is primarily used as a marker for ovarian cancer

A

CA-125

19
Q

This is found as a contaminant of homemade liquors and can cause optic neuropathy

A

Methanol

20
Q

This is a significant environmental pollutant and is easily taken up by crops – especially tobacco

A

Cadmium

21
Q

This is a cardioactive drug that is used to treat arrythmias and CHF. Biotin is known to interfere with this test

A

Digoxin

22
Q

The most direct and effective route of administration of a drug

A

IV

23
Q

This is a common malignant tumor in kids associated with high levels of plasma, epinephrine, norepinephrine and dopamine

A

Neuroblastoma

24
Q

This test is used along with hCG to classify nonseminomatous tumor

A

AFP

25
Q

This is a kind of testing method that can be performed on solid tissue tumor markers

A

Immunohistochemistry

26
Q

The predicted dose that would produce a toxic response in 50% of the population

A

TD50

27
Q

This may occur when analyte concentrations exceed the analytical range excessively

A

Hook Effect

28
Q

This drug is the hepatic metabolite of procainamide

A

NAPA

29
Q

The study of the movement of drugs in the body

A

Pharmacokinetics

30
Q

This drug commonly is tested for both the total and free forms

A

Phenytoin (Dilantin)

31
Q

Endogenous substances biologically synthesized either in living cells or in microorganisms

A

Toxins

32
Q

This method of analysis of toxic agent has good sensitivity but lacks specificity

A

Screening

33
Q

These types of tumor markers are valuable in diagnosing neuroblastomas, pituitary and adrenal adenomas

A

Endocrine Tumor Markers

34
Q

This tumor marker is the prototypical oncofetal antigen and is used for monitoring colorectal cancer

A

CEA

35
Q

Uses the results from animal experiments to predict what level of exposure will cause harm to humans

A

Descriptive Toxicology

36
Q

This is a metal with 3 forms, one of which is liquid at room temp

A

Mercury

37
Q

This is a useful system to compare relative toxicities of substances as the predicted endpoint is death

A

Dose-Response Relationship

38
Q

B-macroglobulin and immunoglobulins are part of this group of tumor markers

A

Serum Protein Tumor

39
Q

Chemicals and drugs that are not normally found in or produced by the body

A

Xenobiotics

40
Q

“Trace Element Free”

A

Royal Blue top tube

41
Q

This is an example of something that can have significant interference in immunoassays by cross-linking with the capture/label antibody

A

HAMAs

42
Q

This drug is ototoxic enough that it is recommended that baseline audiology testing is performed

A

Tobramycin

43
Q

This type of tumor marker can help to choose between endocrine and cytotoxic therapies

A

Receptor Tumor Marker

Chem I (14 decks)

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