Exam 4

Question 1

cimetidine + metformin =

Answer 1

lactic acidosis

Question 2

pioglitizone is not for which patient population

Answer 2

Heart Failure –> fluid retention

Question 3

Non insulin DM drug that can cause liver dysfunction?

Answer 3

acarbose

Question 4

2 non insulin DM that are Sub Q

Answer 4

exanatide and pralmintide

have to go under the tide (water) to give it (water is the skin)

Question 5

DM drugs to give 30-60 minutes before meal

Answer 5

coming soon

Question 6

DM drugs to give with the tray

Answer 6

aspart (rapid)

acarbose ( w/ first bite of food)

Question 7

DM drug that has 1 week formulation

Answer 7

exanatide

Question 8

which n/v drug has risk of prolonged qt interval?

Answer 8

ondansetron ….use caution in bradycardia, electrolyte abnormalities

Question 9

which n/v drug to treat gastroenteritis

Answer 9

ondansetron

Question 10

which antiemtic drug can’t mix w/ warfarin and oral contraceptive?

Answer 10

aprepitant

Question 11

which anti emetic drug has sxs of asthenia (loss of strength/energy) ?

Answer 11

aprepitant

Question 12

which n/v drug has an unknown MOA ?

Answer 12

dexamethasone

Question 13

which n/v drug can cause retrograde amnesia ?

Answer 13

lorazepam

Question 14

which n/v drug is used to treat toxins

Answer 14

metoclopramide (dopamine antagonist)

Question 15

which n/v drug has risk of extravasation?

Answer 15

promethazine (phenothiazine – dopamine antagonist)

Question 16

which n/v drug is used as anti-emetic + improve motility

Answer 16

promethazine

Question 17

which n/v drug cannot be used in <2 year old b/c of risk of resp depression

Answer 17

promethazine

Question 18

which n/v drug when used long term can cause irreversible tardive dyskinesia ?

Answer 18

promethazine

Question 19

which n/v drug can also stimulate apetite?

Answer 19

dronabinol

Question 20

which n/v drug can cause dysphoria and temporal disintegration?

Answer 20

dronabinol

Question 21

which n/v drug is used to treat motion sickness?

Answer 21

hydroxyzine

Question 22

where does hydroxyzine work?

Answer 22

muscarinic receptors in the inner ear

Question 23

which drug for IBD inhibits prostaglandins?

Answer 23

sulfalazine (5 amino salicylate)

Question 24

which GI drug do we need to check for sulfa allergy with?

Answer 24

sulfalazine

Question 25

Do we give sulfalazine before or after meals?

Answer 25

after

Question 26

Which IBD drug can cause joint pain (arthralgia)

Answer 26

sulfalazine

Question 27

use of sulfonylurea's (glipizide) with which drug will increase risk of hyopglycemia?

Answer 27

exantide (GLT incretin)

Question 28

malaise, hyperventilation, somnolence are s/s of what when taking metformin?

Answer 28

lactic acidosis

Question 29

give oral drugs 1 hour before which 2 non insulin dm meds are given?

Answer 29

exanatide and pramlintide *note both of these are sq injections

Question 30

what class of drugs is glipizide?

Answer 30

sulfonylurea = increase insulin prdxn from pancreas

Question 31

which non insulin drug has cold symptoms

Answer 31

DPP4 inhibitor aka Sitagliptin

Question 32

2 non insulin drugs w/ pancreatitis side effect?

Answer 32

sitagliptin, exanatide

Question 33

can you mix pramlintide w/ insulin?

Answer 33

nope!

Question 34

does pramlintide cause hypogylcemia?

Answer 34

if mixed with insulin - occurs 3 hours after

Question 35

non insulin DM med w/ risk of amputation and urosepsis?

Answer 35

canagliflozin

Question 36

cimetidine does not play nicely w/ which 2 non insulin DM drugs?

Answer 36

metformin (biguanide) and glipizide (sulfonylurea)

Question 37

which drug for IBD inhibits tumor necrosis factor?

Answer 37

infliximab

Question 38

which laxative needs to be taken with FOOD and water?

Answer 38

lubiprostone

Question 39

which laxative is for treating IBS, chronic/idiopathic constipation, and opioid constipation?

Answer 39

lubiprostone

Question 40

omeprazole vs cimetidine - how long to take?

Answer 40

``` cimetidine = 4-6 weeks omeprazole = 4-8 weeks ```

Question 41

can cause hypoglycemia

Answer 41

1. glipizide 2. repaglinide 3. acarbose (w/ insulin/sulfonylurea) 4. exanatide (w/sulfonylurea) 5. pramlintide (w/ insulin) + aspart and NPH have risk

Question 42

non insulin DM that causes GI symptoms

Answer 42

1. metformin 2. pioglitizone 3. exanatide 4. pramlintide

Question 43

non insulin DM drugs (2) that causes hypoglyceimia and weight gain

Answer 43

1. glipizide | 2. repaglinide