exam 3

Question 1

drugs we need to know about overdosing/toxicity

Answer 1

imipramine- suicide risk, messes up your<3
lithium - no antidote- .4-.8
phenytoin- 10-20 mcg
triazolam

Question 2

schedule 5?

Answer 2

gabapentin, pregabalin

Question 3

no grapefruit and rash report?

Answer 3

carbamezapine (epilpep)

Question 4

epileptic drug that is hepatotoxic and blood dyscrasia?

Answer 4

valproic acid

Question 5

purple glove and gums?

Answer 5

phenytoin

Question 6

Temporary paresthesia and itching (groin)

Answer 6

fosphenytoin

Question 7

drug increases its own metabolism?

Answer 7

carbamezepine

Question 8

Serotonin Syndrome (SES) vs Serotonin Withdrawal Syndrome

Answer 8

—–Serotonin Withdrawal Syndrome

Dizziness, headache, nausea, sensory disturbances, tremor, anxiety, dysphoria
- Begins within days to weeks , Persists 1-3 weeks

—–Serotonin Syndrome (SES)
mental status changes, hypertension, tremors, fever and sweats, hyperpyrexia, or ataxia
-2-72 hours after treatment starts

Question 9

these 2 block reuptake if serotonin and NE

Answer 9

imipramine (Tofranil)

venlafaxine (Effexor)

Question 10

imiprinine does not play nice w/ which other class of antidepressant?

Answer 10

MAOI

Question 11

drugs to give @ bedtime

Answer 11

-imipramine

late in day = donepezil

Question 12

take in morning

Answer 12

• alendronate
• fluoxetine
• selegiline
• pramipexole

Question 13

MAOI + other antidepressant or sympathomimetic=

Answer 13

hypertensive crisis

Question 14

MAOI + antihypertensive=

Answer 14

hypotension

Question 15

MAOI + antidiabetic drugs=

Answer 15

hypoglycemia

Question 16

MAOI + meperidine (Demerol)=

Answer 16

hyperpyrexia

Question 17

14 day window b/w taking antihypertensive, antidiabetic, meperidine, other antidepressants with _______

Answer 17

MAOI

Question 18

MAOI + Tyramine foods =

Answer 18

hypertensive crisis

Question 19

dosing for colchicine

Answer 19

1.2 mg loading then .6 mg I hr later. Max 1.8/24 hrs.

Question 20

no grapefruit and rhabdo?

Answer 20

colchicine

Question 21

this drug has only one regular side effect but cannot play with warfarin

Answer 21

allopurinol

Question 22

penia vs porosis scores

Answer 22

Osteopenia- low bone mass T-score -1 to -2.5

Osteoporosis- T score -2.5 or more

Question 23

calcium + ______ _______ containing foods = sad

Answer 23

oxalic acid

Question 24

dosing for Ca and Vit D

Answer 24

Ca = 1200 / 2

Vit D = 800-1000

Question 25

intranasal Osteoporosis drug?

Answer 25

calcitonin salmon

Question 26

OP drug w/ esophagitis risk

Answer 26

alendronate

Question 27

2 drugs w/ osteonecrosis of jaw risk

Answer 27

alendronate | denosumab

Question 28

OP drug w/ risk for DVT an PE

Answer 28

SERM - think blood SERuM

Question 29

RANKL goes w/ who

Answer 29

denosumab RANK receptor stimulates formation of osteoclasts -this drug prevents receptor activation and inhibits osteoclast formation- aka RANKL inhibitor

Question 30

SQ OP drugs

Answer 30

calictonin-salmon denosumab teripartide Deno came to Teri's party in Cali

Question 31

SQ- etanercept or methotrexate?

Answer 31

etanercept

Question 32

test for TB prior, watch for hep b activation=

Answer 32

etanercept, methotrexate

Question 33

use folic acid supplement to help your tummy w/ which drug

Answer 33

methotrexate p.s. category x

Question 34

all benzo's potentiate

Answer 34

GABA

Question 35

flumazenil (Romazicon) is antidote for ________. It is given how?

Answer 35

triazolam over 15 seconds. Repeat Q min. Effects last 1 hour.

Question 36

3 drugs = no grapefruit =

Answer 36

colchicine carbamezpine buspirone Don't bring a Grapefruit in my Car or the Bus or the Colcheesey factory

Question 37

prolonged qt interval long term use?

Answer 37

hydroxyzine

Question 38

prototype for benzo anxiety?

Answer 38

diazepam

Question 39

triazolam effects what 3 systems

Answer 39

cns, cv, resp

Question 40

avoid high protein meal with?

Answer 40

levadopa

Question 41

anticholinergic effects with

Answer 41

amantadine benztropine imipramine

Question 42

bronchoconstriction w/ what alz drug?

Answer 42

donepezil (increase ACH)

Question 43

ACH and alz ? ACH and Parkinsons?

Answer 43

``` ALZ = not enough ACH Parkinson's = too much ACH ```

Question 44

nystagmus w/ what 2 antiep

Answer 44

- phenytoin- toxicity | - gabapentin- regular side effect

Question 45

suppress your bone marrow

Answer 45

carbamezepine | methotrexate

Question 46

admin rate for phenytoin? only compatible w? what kind of fluids?

Answer 46

<50mg/ min = SLOW NS