Exam 4: Dr. Sullivant Vaccine Immunology Flashcards Preview

Immunology - DVM year 1 > Exam 4: Dr. Sullivant Vaccine Immunology > Flashcards

Flashcards in Exam 4: Dr. Sullivant Vaccine Immunology Deck (38):
1

Describe passive immunization

Transfer of ready-made antibodies to an individual
Provides immediate humoral protection
Does not induce an immune response from the host (no memory)

2

What are clinical examples of passive immunization?

Rabies post-exposure prophylaxis in humans
Tetanus antitoxin
Pit viper antivenin
Plasma transfusions

3

What are the methods of passive immunization via transfer of maternal antibodies?

Passive transfer of maternal antibody through placenta
Ingestion of colostrum via initial suckling

4

What happens with the GI tract with suckling to get colostrum?

It has maximal permeability to proteins from 0-4 hours, closes by approximately 24 hours

5

What is the pro of passive immunization via transfer of maternal antibodies?

Provides immediate protection of the neonate against pathogens and lasts for 6-16 weeks of age, on average

6

What is the con of passive immunization via transfer of maternal antibodies?

Can interfere with vaccination of neonate via binding of maternal antibody to the antigen in the vaccine (known as immunity gap)

7

What is the strategy of passive immunization via transfer of maternal antibodies?

Administer multiple, sequential vaccines to puppies and kittens until at least 16 weeks of age
--1st vaccine: initial response/recognition takes 10-14 days with maximum response at 3 weeks
--2nd vaccine: leads to immunological memory
--3rd and 4th vaccine: stronger and more rapid memory

8

What is the immunity gap?

Maternal Ab can do this even when the level of antibodies is not sufficient to protect against pathogens
Vulnerable window of time where there is a little too much of the mother's antibodies

9

What are the different types of vaccines?

Killed
Modified-live

10

What are killed vaccines?

Organism is completely inactivated
May require adjuvant to stimulate immune system

11

What is modified-live vaccine?

Organism is modified to a less virulent state (attenuated)

12

What are the pros of MLV?

Rapid and prolonged protection
Stimulates CMI and long-lived humoral immune response
Reduced allergenicity
Stimulates secretory antibody
Lower antigen mass needed
Single dose effectiveness

13

What are the cons of MLV?

No preservatives for storage
Requires multiplication in host
Susceptible to inactivation
Risk of reversion to virulence
Can produce vaccine-induced illness in immunosuppressed hosts
Vaccinates can shed into environment

14

What are the pros to killed vaccines?

No reversion to virulence
Stability in storage
Increased immunity with added adjuvants
Safe in immunosuppressed animals
Vaccinates do not shed organisms

15

What are the cons to killed vaccines?

Stimulates humoral immunity
Minimum of 2 doses needed for protection
Increased risk of allergic complications
Shorter duration of immunity
Adjuvants frequently required*
Ag may not induce proper Ab if too denatured

16

What are adjuvants?

Substance that enhance the immunogenicity of vaccines that stimulate cell-mediated immunity

17

What are adjuvants used with?

Killed organisms or purified antigens

18

What do adjuvants attempt to do?

Increase duration and amount of immuno-stimulation equal to MLVs

19

What do adjuvants produce?

Heightened inflammatory reaction–good or bad

20

What is the underlying theme of sarcoma development in cats?

Inflammation

21

Where is the rabies vaccine site?

As low as possible on the lateral right hindlimb (below stifle)

22

Where is the FeLV vaccine site?

As low as possible on the lateral left hindlimb (below stifle)

23

Where is the FPC/FHV-1/FCV vaccine site?

Lateral aspect of right forelimb below elbow

24

When are core vaccines used?

Infection has high risk of morbidity and mortality
Infections are of public health concern
Infections are readily transmitted
Infections are ubiquitous in environment
Safe, efficacious vaccines are available
Vaccines prevent infection or decrease clinical signs

25

What are examples of canine core vaccines?

DA2P (distemper, adenovirus, and parvovirus)
Rabies

26

What are non-core vaccines used for?

Vaccine may have limited efficacy
Disease is not readily transmitted
Limited geographic disturbance or prevalence
Disease is mild
Vaccines may interfere with diagnostic screening

27

What are examples of canine non-core vaccines?

Leptospirosis
Bordetella

28

What are examples of feline core vaccines?

FVRCP (Feline viral rhinotracheitis, calicivirus, and panleukopenia)
Rabies
Feline leukemia virus

29

What are the recommendations for feline viral rhinotracheitis?

Cats can persistently shed virus
Prevention before exposure is key
MLV or killed vaccine at 6-9 weeks old (right front)
Kittens need 2nd vaccine 4 weeks later
Last vaccine at 16-20 weeks old
Vaccinate 1 year later
Then every 3 years

30

What are the recommendations for feline rabies?

Initial vaccine at 12 weeks with recombination vaccine or killed
Distal right hindlimb
Give recombinant vaccine annually
Check state and local regulations

31

What are the recommendations for FeLV?

Recommended to vaccinate when less than 1 year and booster in 1 year
Viral screening of all kittens with ELISA prior to vaccination
Use killed or recombinant vaccine at 1st or 2nd kitten visit
Then 4 weeks later
Then 1 year after last kitten vaccine
Left hind limb
Becomes non-core vaccine for adult cats

32

What are the feline non-core vaccines?

Chlamydiosis
Bordetella

33

What is a feline vaccine that is not recommended?

Feline immunodeficiency virus

34

What is used for the diagnosis of feline immunodeficiency virus?

SNAP test is used for antibodies to FIV, so vaccinated animals are positive

35

What happens when vaccinating older animals?

Can mount an adequate immune response
2 vaccination given 3-4 weeks apart are considered protective in dogs and cats older than 16 weeks
One MLV would likely also be protective
Booster at 1 year for first vaccination, then every 3 years
Duration of immunity has been shown to be up to more than 5 years for many core products

36

What is an adverse reactions for cats?

Feline injection site sarcomas

37

How can you protect from adverse reactions?

Avoid adjuvants
3-2-1 rule

38

What is the 3-2-1 rule?

Persists for longer than 3 months
Greater than or equal to 2 cm
Increases in size after 1 month