Exam 6 - Hematopoietic Drugs Flashcards Preview

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Flashcards in Exam 6 - Hematopoietic Drugs Deck (24):
1

Causes of anemia

- blood loss
- hemolysis
- inadequate erythropoiesis
- drugs
- infections, cancer, chronic inflammation
- iron, folic acid, vitamin B12 deficiency

2

Orally administered and used to prevent or treat iron deficiency (microcytic anemia)

- ferrous sulfate
- polysaccharide-iron complex

3

How much iron needs to be administered for deficiency?

100-200 mg/day of elemental iron
4-6 months is required

4

Iron adverse effects

- N&V
- diarrhea or constipation
- black stool
- liquid can stain teeth

5

Iron interactions - reduce absorption of iron

- bile acid resins
- antacids
- H2 antagonists
- proton pump inhibitors (PPIs)

6

Iron interactions - increase absorption of iron

ascorbic acid

7

Iron interactions - in which iron reduces the absorption

(separate 2 hours)
- tetracyclines
- fluoroquionlones (e.g. ciprofloxacin, levofloxacin)
- levothyroxine

8

Ferric gluconate adverse effects

(IV iron)
hypotension, pruritus

9

Iron sucrose adverse effects

(IV iron)
- hypotension, pruritus

10

Ferumoxytol adverse effects

- hypotension
- hypersensitivity reactions
- alter magnetic resonance imaging studies for up to 3 months after the last dose

11

Ferric carboxymaltose adverse effects

- hypersensitivity reactions
- HYPERTENSION
- flushing
- hypophosphatemia

12

Folic acid indications

- preventing and treating megaloblastic anemia (associated folic acid deficiency
- preventing spina bifida

13

What drugs can cause folic acid deficiency?

- trimethoprim
- methotrexate
- oral contraceptives

14

What drugs can inhibit folic absorption?

Cholestyramine
Phnytoin

15

B12 pharmacokinetics

- given orally
- administered IM
- given intranasally

16

B12 indications

treating B12 deficiency

17

B12 drug interactions

- metformine
- proton pump inhibitors (Prilosec)
- H2 receptor antagonists
- colchicine
- nitrous oxide (chronic abuse)

18

Epoetin

Hematopoietic growth factor

19

Darbepoetin

Hematopoietic growth factor

20

Epoetin and Darbepoetin administation

- administered parenterally to treat hematopoietic deficiencies
- need iron to maintain and support erythropoiesis

21

Epoetin and Darbepoetin adverse effects

- hypertension
- seizures
- thrombosis
- pure red cell aplasia

22

Pegfilgrastim

hematopoietic growth factor
- longer half life

23

Filgrastin

hematopoietic growth factor

24

Filgrastim and pegfilgrastim indications

- neutropenia associated w/ cancer chemotherapy
- bone marrow transplantation