Exam IV: Autonomics Flashcards Preview

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Flashcards in Exam IV: Autonomics Deck (40):
1

Rifampin

Inhibits RNA polymerase

2

If patient has respiratory tract infection and non compliant

Give azithromycin because only once daily

3

Broth dilution test, what MIC value has the greatest bacterial kill?

MIC: the smaller the better

4

Protein Synthesis Inhibitors

Macrolides and tetracycline, clindamycin, and erythromycins

5

Drug of choice for C diff

Metronidazole

6

Drug of choice for lyme disease

Doxycycline

7

What class of drugs has post antibiotic effect (PAE) and concentration killing rate (CDKR)?

Aminoglycosides = once daily dosing because have PAE because if falls below therapeutic range it still has effects

8

Patient dx with syphilis and non-compliant

IM benzapene penicillin, NEVER IV

9

Interaction with Coumadin with ciprofloxacin

Increased anti coagulation effect = quinolone

10

Cephalosporin that covers anaerobic infections (2nd generation)

Cefoxitin and Cefotetan

11

Best covers gram positive best, as well as streptococci?
Best gram negative coverage?

Gram positive/strep: Clarithromycin
Gram negative: Azithromycin

12

Alcoholic took this medication, and now vomiting

Metronidazole (administered orally or vaginally) can result in a disulfiram-like reaction characterized by flushing, tachycardia, palpitations, nausea, and vomiting

13

Blocks bacterial translation by reversibly binding to the 16S rRNA in the 30S subunit/ blocks protein synthesis

Tetracycline

14

Most common way of microbial resistance

Break beta lactam ring of drug via beta lactamases (microbial enzymes)

15

What effects do Belladonna drugs have?

Cause mydriasis/eye dilation
Muscarinic receptor antagonists, undo cholinergic so used to treat sinus bradycardia given via IV

16

What is used to treat COPD?

Ipratropium

17

Only depolarizing neuromuscular blocking agent (block ACh at nicotinic receptor)

Succinylcholine

18

What is used to treat pheochromocytoma?

Phenoxybenzamine

19

Selective beta 1 blocker used to treat BPH

Tamsulosin
BPH also treated by doxazosin, alfuzosin, silodosin

20

Bronchodilator to treat asthma

Albuterol

21

Beta blocker for intraocular pressure for glaucoma patients

Timolol, only one that is an eye drop

22

Sympathetic NS Effects

Dilate pupils, decrease secretions, inhibits salivation, increase HR, inhibits bladder contraction, secretion of adrenaline, stimulates glucose production

23

Parasympathetic NS Effects

Contracts bladder, constricts pupil, stimulated bile release stimulates flow of saliva. constricts bronchi

24

Which is the primary neurotransmitter at post-ganglia junction for sympathetics

NE

25

Increase HR and contractility

beta 1 receptors

26

Which medication blocks alpha and beta receptors

Labetalol beta 1 and beta 2, alpha 1 blocker decreases heart rate and blood pressure

27

Direct acting ACh agonist used for glaucoma on nicotinic and muscarinic

Pilocarpine

28

Which drug is used for lice?

Malathion prescription not over counter

29

Older male patient presents with BPH and ED, which drug would you prescribe?

Tadalafil

30

Drugs used to treat Alzheimer's Disease

Rivostigmine, donepezil, galantamine to increase ACh in CNS

31

Indirect ACh receptor agonist

Inhibit cholinesterase

32

Which of the following is an effect of muscarinic receptor antagonist?

increase HR and bronchodilation
Basically cause sympathetic reactions

33

What can be used for IBS and spasms?

Hyoscyamine to decrease GI motility

34

What is used to treat overactive bladder?

Oxybutyin, tolterodine, darifenacin, solifenacin, and trospium
Decrease urination because anti cholinergic (cholinergic increases urination) and muscarinic antagonist (against parasympathetic, so sympathetic effects)

35

What drug that is a synthetic catecholamine muscarinic antagonist is used for bronchodilation?

Ipratropium and tiotropium are for bronchodilation; muscarinic antagonist; anti-cholinergic

36

Which synthetic muscarinic antagonist is used to increase mydriasis?

Tropicamide

37

Which non-depolarizing neuromuscular blocker eliminated renally has the longest action?

Pancuronium

38

What is synthetic adrenoceptor agonist?

Isoproterenol and dobutamine

39

Have a physician who wants to do open heart surgery: which one stimulates beta 1 and vasodilation of beta 2?

Dobutamine

40

Which drug is used for cardiovascular failure?

Carvatolol
Alpha and beta (1 and 2) blocker
Increases cardiac output