Excretion Flashcards
(6 cards)
1
Q
What is drug excretion?
A
The removal of a drug and/or its metabolites from the body
2
Q
Factors that affect urinary excretion include
A
GRF
Tubular reabsorption by passive diffusion
Tubular secretion of a drug via active transport
3
Q
What size drugs can pass through glomerular filtration
A
<60kD
4
Q
Urinary excretion is affected by?
A
Renal blood flow
Degree of drug binding to the plasma proteins
GFR
5
Q
Creatinine is a measure of what?
A
Breakdown of muscle
6
Q
Why does serum creatinine in urine relate to GFR
A
SC is nearly 100% excreted in the kidneys
