export_circulatory viruses i only ebv Flashcards Preview

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Flashcards in export_circulatory viruses i only ebv Deck (20):
1

EBV diseases

Mono
Oral hairy leukoplakia

Burkitt's lymphoma

Hodgkin's disease

Nasopharyngeal carcinoma

PTLD

2

EBV virus family and features

Herpesviridae
Enveloped, dsDNA

Uses C3d component of complement for attachment and entry, replicates within epithelial and B cells

3

Latent membrane protein 1

6 transmembrane-spanning domains
CD40 homologue

Constitutively active receptor

Increased growth and suppressed apoptosis

4

Latent membrane protein 2

Increased growth of B cells

5

Epstein Barr virus nuclear Ag 1

Transactivation of EBV transforming genes
Inhibit apoptosis

6

Mono symptoms

Fever, malaise, splenomegaly

7

Biochemical marker of mono

Heterophile Abs

8

Pathogenesis of mono

Immune targeting of infected B cells

9

Mono diagnosis

Mono spot test (RBC agglutination)
Abs to EBV (IgM to viral capsid Ag)

Downey cells

10

Treatment of mono

Rest and hydration
Avoiding strenuous activity (splenic rupture)

11

Oral hairy leukoplakia

Typically in immunocompromised individuals
Active EBV replication

12

Oral hairy leukoplakia treatment

Antiherpetic drugs
Podophyllin resin

13

Cause of Burkitt's lymphoma

Genetic translocation of MYC gene into Ig gene resulting in high levels of MYC in these B cells
Highly associated with EBV

14

Co-factors for Burkitt's lymphoma

Chronic malaria (endemic form)
Immunosuppression

15

Diagnostic feature of Hodgkin's disease

Reed-Sternberg cells

16

Treatment of Hodgkin's disease

Radiotherapy and/or chemotherapy

17

Nasopharyngeal carcinoma

Epithelial cell cancer originating in the nasopharynx

18

Post-transplantation lymphoproliferative disorder (PTLD)

Abnormal proliferation of lymphoid cells in transplant patient

19

PTLD diagnosis

Histological analysis of tissue
EBV infection at time of transplant is the major risk factor, so detection of EBV genome via in situ hybridization

20

PTLD treatment

Reduce immunosuppression
Rituximab

Conventional chemotherapy