extra antimicrobial Q's

Question 1

When a patient has an enterococci infection, which of the following should you give him?

a. penicillin
b. cephalosporin

Answer 1

a. penicillin

cephalosporin is less active against enterococci

Question 2

Which TWO of the following is active against Pseudomonas app.?

a. Cephalexin
b. Ceftazidime
c. Cefuroxime
d. Cefoxitin
f. Cefotaxime
d. Cefazolin
e. Cephepime

Answer 2

b. Ceftazidime
&
e. Cephepime

Question 3

When a patient is allergic to penicillin, should a physician use cephalosporin instead?

Answer 3

No, there’s a cross reaction of 10%

use glycopeptides instead

Question 4

Which of the following is usually mixed with cilastatin?

a. meropenem
b. imipenem
c. aztreonam

Answer 4

b. imipenem

Question 5

Which of the following does NOT cause seizures?

a. meropenem
b. imipenem
c. aztreonam

Answer 5

c. aztreonam

Question 6

beta-lactams are

a. bacteriostatic
b. bactericidal

Answer 6

b. bactericidal

Question 7

Which is FALSE about the first natural penicillin?

a. produced by penicillum
b. broken down by gastric acids
c. broad range
d. high excretion rate

Answer 7

c. broad range

Question 8

Which of the following is an oral penicillin?

a. piperacillin
b. temocillin
c. penicillin V
d. benzyl & procaine penicillin

Answer 8

c. penicillin V

Question 9

Which of the following is anti-pseudomonas aeruginosa?

a. piperacillin
b. temocillin
c. penicillin V
d. benzyl & procaine penicillin

Answer 9

a. piperacillin

Question 10

Which of the following is beta-lactamase resistant?

a. piperacillin
b. temocillin
c. penicillin V
d. benzyl & procaine penicillin

Answer 10

b. temocillin

Question 11

Which of the following is active against Hemophilus?

a. Cefuroxime
b. Cefazolin
c. Cephalexin

Answer 11

a. Cefuroxime

also active against S. pneumoniae

Question 12

Which of the following can be used for meningitis?

a. cefotaxime
b. cefoxitin
c. cloxacillin
d. cefazolin

Answer 12

a. cefotaxime

cefotaxime and ceftriaxone can cross the BBB

Question 13

Which of the following is given parenterally?

a. piperacillin
b. temocillin
c. penicillin V
d. benzyl & procaine penicillin

Answer 13

d. benzyl & procaine penicillin

Question 14

Which of the following is anti-staph?

a. ceftazidime
b. cefoxitin
c. cloxacillin
d. cefazolin

Answer 14

c. cloxacillin

Question 15

Which of these is used against enterobacteria?

a. Cephalexin
b. Amoxicillin
c. Ceftazidime

Answer 15

b. Amoxicillin

it’s an extended-spectrum penicillin, while A&C are cephalosporin

Question 16

Which of these isn’t a side effect of Penicillin?

a. vesicular rash
b. neurotoxicity
c. anapylactic reaction
d. urticarial reaction

Answer 16

a. vesicular rash

should be maculopapular rash. tricked you!

Question 17

What occurs when you add an additional carbon to a drug?

a. pharmacokinetic activity decreases
b. the drug becomes more excretable
c. antibacterial activity is enhanced

Answer 17

c. antibacterial activity is enhanced

Question 18

Which of the following can be treated aztreonam?

a. gram negative anaerobic cocci
b. gram negative aerobic cocci
c. gram negative anaerobic bacilli
d. gram negative aerobic bacilli

Answer 18

d. gram negative aerobic bacilli

Question 19

Which of the following is more nephrotoxic?

a. vancomycin
b. teicoplanin

Answer 19

a. vancomycin

should monitor levels on blood

Question 20

Which of the following stops protein synthesis?

a. Sulphonamides & Trimethoprim
b. Rifampicin
c. Nitrofurantoin
d. Quinolones

Answer 20

c. Nitrofurantoin

by messing with mRNA

Question 21

Which of the following inhibit DNA dependent RNA polymerase?

a. Sulphonamides & Trimethoprim
b. Rifampicin
c. Nitrofurantoin
d. Quinolones

Answer 21

b. Rifampicin

Question 22

What do Sulphonamides & Trimethoprim do?

a. directly inhibit DNA synthesis
b. directly inhibit DNA-gyrase
c. indirectly inhibit DNA synthesis
d. indirectly inhibit DNA-gyrase

Answer 22

c. indirectly inhibit DNA synthesis

Question 23

What do Quinolones do?

a. directly inhibit DNA synthesis
b. directly inhibit DNA-gyrase
c. indirectly inhibit DNA synthesis
d. indirectly inhibit DNA-gyrase

Answer 23

b. directly inhibit DNA-gyrase

Question 24

which of these inhibits dihydrofolate reductase?

a. sulphonamide
b. trimethoprime

Answer 24

b. trimethoprime

Question 25

What occurs when you give a person with a G6PD deficiency sulfonamide? a. hematuria b. hemolytic anemia c. megaloblastic anemia

Answer 25

b. hemolytic anemia

Question 26

Which of these can cause stevens-johnson syndrome? a. trimethoprim b. sulphonamide c. vancomycin

Answer 26

b. sulphonamide

Question 27

Which of the following is NOT used for UTI's? a. trimethoprime b. nitrofurantoin c. quinolones d. ciprofloxin

Answer 27

c. quinolones

Question 28

Which TWO of these cause pseudomembranous colitis a. cephalosporin b. glycopeptides c. meropenem d. quinolones e. metronidazole

Answer 28

a. cephalosporin & d. quinolones (& clindamycin)

Question 29

Which of these cause a metalic tast to occur? a. cephalosporin b. glycopeptides c. meropenem d. quinolones e. metronidazole

Answer 29

e. metronidazole

Question 30

Which of these inhibits DNA gyrase? a. Cefotaxime b. Ciprofloxacin c. Cefazolin d. Cephepime

Answer 30

b. Ciprofloxacin | which is a flouroquinolones

Question 31

Patient presents with giardia lamba, what should you treat him with?

Answer 31

metronidazole | its for anaerobes and protozoa

Question 32

What occurs when you give a person with a G6PD deficiency nitrofurantoin? a. hematuria b. hemolytic anemia c. megaloblastic anemia

Answer 32

b. hemolytic anemia | hemolysis

Question 33

Which of the following destroy the cell wall first? a. glycopeptide b. penicillin c. cephalosporin

Answer 33

a. glycopeptide | they act on wall synthesis before the beta lactams

Question 34

Which of these inhibit the earlier stages of folic acid synthesis? a. sulphonamide b. trimethoprime

Answer 34

a. sulphonamide

Question 35

How do macrolides stop protein synthesis? a. bind to 30S ribosome b. bind to 50S ribosome

Answer 35

b. bind to 50S ribosome | clindamycin does this too!

Question 36

Which of the following is known to be nephrotoxic and ototoxic? a. gentamicin b. josamycin c. erythromycin

Answer 36

a. gentamicin

Question 37

which of the following has a side effect of clostridium difficile-associated diarrhea? a. gentamicin b. josamycin c. erythromycin d. clindamycin

Answer 37

d. clindamycin

Question 38

Which of the following binds to 30S ribosome to stop protein synthesis? a. clindamycin b. tetracycline c. josamycin

Answer 38

b. tetracycline

Question 39

Which is used for RTI and STD treatment? a. clindamycin b. tetracycline c. azithromycin d. amikacin

Answer 39

c. azithromycin | along with other macrolides like erythromycin, josamycin, & clarithromycin

Question 40

Which of the following is used for severe sepsis? a. amikacin b. josamycin c. erythromycin d. clindamycin

Answer 40

a. amikacin | any aminoglycoside; like amikacin, gentamicin, & streptomycin

Question 41

Which of the following is used to treat rickettsia? a. clindamycin b. tetracycline c. azithromycin d. amikacin

Answer 41

b. tetracycline | used for atypical bacteria

Question 42

Which two of the following is bacteriocidal? a. fusidic acid b. chloramphenicol c. colistin d. tetracycline e. aminoglycosides

Answer 42

c. colistin & e. aminoglycosides

Question 43

which of the following has a side effect of irreversible bone marrow aplasia? a. fusidic acid b. chloramphenicol c. colistin d. tetracycline

Answer 43

b. chloramphenicol

Question 44

which of the following is never used alone because of fear of resistance? a. fusidic acid b. chloramphenicol c. colistin d. tetracycline

Answer 44

a. fusidic acid

Question 45

Which of these stops the protein synthesis initiation process? a. colistin b. linezolid c. fusidic acid

Answer 45

b. linezolid | oxazolidinones

Question 46

Which of the following damages cartilage? a. tetracycline b. quinolone c. chloramphenicol

Answer 46

b. quinolone | & ciprofloxacin

Question 47

Which of the following causes grey baby syndrome? a. tetracycline b. quinolone c. chloramphenicol

Answer 47

c. chloramphenicol

Question 48

Which of the following damages cartilage? a. colistin b. linezolid c. ciprofloxacin d. fusidic acid

Answer 48

c. ciprofloxacin | & quinolone

Question 49

Which of these has an anti-endotoxin activity that neutralizes LPS? a. colistin b. linezolid c. fusidic acid

Answer 49

a. colistin