FA 2014: Hem Drugs Flashcards Preview

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Flashcards in FA 2014: Hem Drugs Deck (19):
1

LMWHs

Enoxaparin, dalteparin, fondaparinux

2

Mechanism of HIT

IgG against Heparin:PF4 --> thrombocytopenia

3

Treatment of HIT

Direct thrombin inhibitors (argatroban, bivalirudin, leupridin)

4

Direct factor Xa inhibitors

Apixaban, rivaroxaban

5

Direct thrombin inhibitors

Argatroban, bivalirudin, leupridin

6

Mechanism of heparin

Heparin --> antithrombin --> decreased IIa/Xa

7

Treatment for thrombolytic tox

Aminocaproic acid

8

Treatment for heparin tox

Protamine sulfate

9

ASA effect on clotting

Elevated bleeding time, no effect on PT/PTT

10

ASA toxicity

Gastric ulceration, tinnitus, interstitial nephritis, Reye syndrome

Resp alkalosis --> metabolic acidosis

11

ADP receptor inhibitors

Clopidogrel (Plavix), ticlopidine, prasugrel, ticagrelor

12

Neutropenia in patient taking stroke prophylaxis

Ticlopidine effect

13

Mechanism of ADP-R inhibitors

Inhibit platelet aggregation, fibrinogen binding by preventing GpIIb/IIIa binding

14

PDE-III inhibitors

Cilostazol, dipyridamole

15

Mechanism of PDE-III inhibitors

Raise cAMP in platelets --| aggregation, vasodilators

16

Use of PDE-III inhibitors

Intermittent claudication, TIA/stroke prevention, angina prophylaxis

17

GPIIb/IIIa inhibitors

Abciximab, eptifibatide, tirofiban

18

Use of GPIIb/IIIa inhibitors

Unstable angina, PCI angioplasty

19

Toxicity of GPIIb/IIIa inhibitors

Thrombocytopenia, bleeding