FA 2014: Immunology Flashcards
(103 cards)
The growth of germinal centers from B cells depends on 3 elements: name them.
T cell, antigen, and CD40L
Dense and dormant follicles
Primary follicles
Pale central germinal centers, active follicles
Secondary follicles
No B cell follicles
Agammaglobulinemia
Plasma cells and lymphocytes, tightly packed in LN
Medullary cords
The medullary cords in the LN correspond to the ___ in the spleen
Red pulp
The diffuse cortex in the LN corresponds to the ____ in the spleen
PALS
Postcapillary (high-endothelial) venules
Where B/T cells enter paracortex from the blood
No paracortex or poorly developed
DiGeorge Syndrome
R. lymphatic duct drains ___
R side of body above diaphragm
Popliteal LN drain ___
Dorsolateral foot, posterior calf
Superficial inguinal LN drain ___
Anal canal below pectinate line, skin below umbilicus (except popliteal territory)
Para-aortic LN drain __
Kidneys, ovaries, testes, uterus
Internal iliac LN drain ___
Lower rectum to anal canal above pectinate line, bladder, vagina, prostate
Sinusoids of spleen: describe histo
Long vascular channels with fenestrated “barrel loop” BM and nearby macrophages (red pulp)
Spleen is protected by ribs ____
9-12 posterolaterally
White pulp in spleen contains ___
T cells (PALS) and B cells (follicles)
Marginal zone
Crossover between white/red pulp, contains APCs and specialized B cells
How does splenic dysfunction lead to susceptibility to encapsulated organisms?
IgM down –> complement activation reduced –> reduced C3b opsonization –> increased susceptibility to SHiNE SKiS organisms
SHiNE SKiS
Encapsulated organisms: s. pneumo, h.flu, n. meningitidis, e. coli, salmonella spp., klebsiella, group B strep
Post-splenectomy findings
Howell-Jowell bodies (nuclear remnants), target cells, thrombocytosis
How does thalassemia impair the spleen?
Red pulp SHOVES white pulp THE FUCK OUT OF THE WAY
Spleen produces ____ of the body’s Ig
50%
Thymus cortex is ___ and contains immature T cells
Dark
