FA Run #2 Flashcards Preview

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Flashcards in FA Run #2 Deck (9):
1

Amino acids necessary for purine synthesis

GAG - glycine, aspartate, glutamine

2

Mechanism of de novo purine synthesis

1. Start with sugar (ribose-5-P) and phosphate (PRPP)
2. Add base

3

Mechanism of de novo pyrimidine synthesis

1. Make temporary base (orotic acid)
2. Add sugar (ribose-5-p) and phosphate (PRPP)
3. Modify base

4

Mycophenolate and ribavirin inhibit ____

IMP DHGN

5

Leflunomide inhibits ____

Dihydroorate DHGN

6

6-MP and azathioprine inhibit __

De novo purine synthesis

7

5-FU inhibits ___

Thymidylate synthase

8

MTX, TMP, and pyrimethamine inhibit ___

DHFR

9

Carbamoyl phosphate is involved in 2 pathways. . . which?

Urea cycle and de novo pyrimidine synthesis