FA 2016 pg 444-449 MuscSk

Question 1

Anti inflammatory agents blocks an enzyme that converts ———-to arachidonic acid

Answer 1

lipids

Question 2

which drug does not participate in the corrosive effect of G.I Lining.

Answer 2

celecoxib (COX2 only)

Question 3

what is the MOA of Aspirin?

Answer 3

Irreversible blockers of Cox 1 & 2

Question 4

List 5 reversible blockers of COX 1 & 2

Answer 4

diclofenac, ibuprofen, indomethacin, ketorolac Naproxen

Question 5

what drug blocks 5 Lipoxygenase

Answer 5

ZIleuton

Question 6

list two drugs that block leukotrienes receptors

Answer 6

montelukast zafrilukast

Question 7

List the chemotaxic agents

Answer 7

LTB4, IL8, C5a, bacteria cell wall

Question 8

what leukotrienes increase bronchial tone

Answer 8

LTC4, D4 & E4

Question 9

what drug is an analog prostaycin i-2

Answer 9

Epoprostenol

Question 10

what are the functions of prostacyclins

Answer 10

Inhibit platelet aggregation & decrease vascular tone & promote vasodilation

Question 11

Prostaglandin E1 function and what drug is associated with it

Answer 11

dec vascular tone (ALoprostadil)

Question 12

what drug increase uterine tone

Answer 12

Dinoprostone (PGE2)

Carboprost (PGF2alpha)

Question 13

two function of thromboxane

Answer 13

inc platelet aggregation

inc vascular tone

Question 14

what is the function of alprostadil?

Answer 14

dec vascular tone

Question 15

Acetaminophen MOA?

Answer 15

reversible inhibit cycloxygenase mostly in CNS

Question 16

what are the clinical use of Acetaminophen

Answer 16

antipyretic, analgesic & NOT INFLAMATORY

Question 17

what drug can be substituted in children to prevent Reye Syndrome

Answer 17

Acetaminophen

Question 18

SE of Aceetaminophen

Answer 18

hepatic necrosis

Question 19

describe the process of acetaminophen induced hepatic necrosis

Answer 19

NAPQI depletes glutathione and forms toxic tissues byproduct in the liver

Question 20

what is an antidote for Acetaminophen overdose

Answer 20

N-Acteylcysteine (regenerating glutathione)

Question 21

what other disease is N-acetylcsteine used to treat and describes its MOA

Answer 21

C.F and weakens mucous plugs

Question 22

what drug irreversibly inhibits COX 1 & 2

Answer 22

Aspirin

Question 23

by what process does Aspirin used to inhibit CoX

Answer 23

Covalent Acetylation

Question 24

inc bleeding time and no effect on PT & PTT is seen in what drug

Answer 24

Aspirin (Effects last until new platelets are produced)

Question 25

what is the function of aspirin at low dose ?

Answer 25

dec platelet aggregation

Question 26

what is the function of aspirin at medium dose (300- 2400mg/day)

Answer 26

Antipyretic & analgesic

Question 27

what is the function of aspirin at high dose (2400-4000mg/day)

Answer 27

Anti- Inflammatory

Question 28

Tinnitus is caused by what anti-inflammatory medication

Answer 28

Aspirin

Question 29

what drug causes early respiratory alkalosis and late mixed metabolic acidosis-respiratory alkalosis

Answer 29

Aspirin

Question 30

Varicella zooster and Influenza B is seen in what pathology affecting kids

Answer 30

REye

Question 31

conjunctivitis, Rash, Adenopathy and a red inflamed tongue can be treated by

Answer 31

Aspirin

Question 32

function of COX 1

Answer 32

Maintain gastric Mucosa

Question 33

what drug increases the risk of thrombosis and could cause allergy in some patients

Answer 33

celecoxib (Sulfa Allergy)

Question 34

Mediates inflammation and pain and spares Cox 1

Answer 34

Celecoxib

Question 35

clinical use of celecoxib

Answer 35

osteoarthritis and Rheumatoid Arthritis

Question 36

NSAIDS Reversible inhibit COX 1 & 2 T or F?

Answer 36

T

Question 37

what drug blocks prostaglandin synthesis

Answer 37

NSAIDS

Question 38

what drug closes PDA

Answer 38

NSAIDS (Indomethacin)

Question 39

what is the role of prostaglandin in the kidneys?

Answer 39

Vasodilator afferent arterioles

Question 40

Bonus: what drug constrict efferent arterioles

Answer 40

Angiotensin 2

Question 41

What drug has a side effect of renal Ischemia

Answer 41

NSAIDS

Question 42

MOA of Leflunomide and what part of DNA pathway does it block?

Answer 42

Reversible inhibits dihydro-orotate dehydrogenase blocking pyrimidine synthesis

Question 43

which drug surpress T-cell proliferation

Answer 43

Leflunomide

Question 44

4 SE of Leflunomide

Answer 44

Hepatotoxicity, Teratogenic, diarrea and HTN

Question 45

clinical use of Leflunomide

Answer 45

RA, Psoartic arthritis

Question 46

what drug binds hydroxypatite in bone

Answer 46

Bisphosphonate

Question 47

what drug inhibits osteoclastic activity

Answer 47

bisphosphonate

Question 48

what medication should the patient be advised to take with water and remain upright for 30 minutes and why?

Answer 48

Bisphosphonates (causing esophagitis)

Question 49

what drug causes osteonecrosis of the jaw

Answer 49

bisphosphonate

Question 50

what drug causes transient hypercalcemia

Answer 50

teriparatide

Question 51

what drug causes atypical stress fractures

Answer 51

bisphosphonate

Question 52

a recombinant parathyroid analog given subcutaneously daily

Answer 52

teriparatide (inc osteoblastic activity)

Question 53

list the drugs that inhibit xanthine oxidase

Answer 53

allopurinol, febuxostat

Question 54

A recombinant uricase that catalyze metabolism of uric acid to allantoin

Answer 54

Pegloticase

Question 55

Pegloticase is water soluble, T of F

Answer 55

T

Question 56

what drug inhibit reabsorption of uric acid in PCT

Answer 56

probenecid

Question 57

list of drugs to treat acute gout?

Answer 57

NSAIDS (indomethacin, naproxen), Steroids, Colchicine

Question 58

what your drug inhibit microtubule polymerization

Answer 58

Colchicine

Question 59

what drug impairs neutrophils chemotaxis and degranulation with a G.I side effect

Answer 59

Colchicine

Question 60

list the TNF alpha inhibitors use for gout

Answer 60

Etarnacept, infliximab, adalimumab

Question 61

what drug do you use to treat tumor Lysis Syndrome?

Answer 61

Rasburicase

Question 62

What is MOA of rasburicase

Answer 62

recombinant Uricase that catalyze metabolism of uric acid to Allantoin

Question 63

Bonus: what blood drug inhibit microtubule polymerization and what disease do they treat and what fungi drug has the same MOA

Answer 63

vincristine (non-Hodgkin), Vinblastine (Hodgkin), paclitaxel Griseofulvin (Antifungi)

Question 64

QuadTripple BONUS :) :what is the MOA of Erlotinib | whats the S.E??????????????????

Answer 64

EGFR tyrosine kinase Inhibitor used for non small cell lung carcinoma and S.E is rash and photosensitivity

Question 65

bonus : what drug is a mast cell degranulator

Answer 65

cromolyn

Question 66

what can be used to treat hemorrhagic cystitis from cyclophosphamide toxicity?

Answer 66

N-Acetyl cysteine

Question 67

what type of COX is found in platelet and G.I

Answer 67

Cox 1

Question 68

avoid NSAIDS in what diruetics

Answer 68

Loops (dec GFR)

Question 69

Bonus: what loop diuretics should be used in a patient with sulfa allergies

Answer 69

Etharynic acid

Question 70

what drug have no renal effect, but can cause Steven Johnson

Answer 70

Sulindac

Question 71

what drug increase osteoblastic activity for osteoporosis

Answer 71

teriparatide

Question 72

what is the second drug if you can't take bisphosphonate

Answer 72

Raloxifen

Question 73

Bonus: what is the clinical presentation of Lynch Nyhan syndrome?

Answer 73

``` HGPRT Hyperuricemia Gout Pissed off retardation dystonia ```

Question 74

what is MOA of terbinafine

Answer 74

inhibit squalene epoxidase