Farm Flashcards
(20 cards)
Fibrates
Gemfibrozil
Clofibrate
Bezafibrate
Denominate
Up regulate lpl
Increase tg clearance activate
Ppar a
Induces hdl creation
Fibrates
Inhibits conversion from hmg coa
To mevalonate a cholesterol precursor
Startin
Inhibits lipolysis
In adipose tissue reduces hepatic
Vldl
Niacin
Cholesterol blocking drugs
Ezetimibe
Bike acid raisins
Cholestyramine colestipol
Colesevelam
Class 1 anti arrhythmic
Na Chanel blockers
Quinidine procainamide
Disopyramid
Lidocaine mexiletine
Class 1b
Decreases Ap duration preferentially affect ischemic or depolarized purkinje and ventricular tissue
Flecainide propafenone
Class I c
Significantly prolongs refractory period in AV nods
Class 2 beta blockers
Propranolol metoprolol esemolol
Decrease sa and AV nodal activity by decreasing slop of fade 4
Clinical use of class 2 beta blockers
Blocks ca
Svt slowing ventricular rate during a fib and a flutter
K channel blockers
Amiodarone Ibutalide dofetalide soltalol
Mechanism of acting of k channel blockers
Increase Ap duration increase erp raise qt interval
Clinical use of k blocker
A fib a flutter and ventricular tach
Red flushing in face . Hyperurecemia hyperglycemia
Niacin
k channel blockers toxcity
sotalol- torsades de point. essesive B blockade
ibulitilide - torsades de point
amiodarone - pulminary fibrosis
hepatoxicity hypothyroidism/
hyperthyroidism (it is 40 % iodine by wieght)
corneal deposits skin deposits(blue grey
resulting in photodermatisis
neurological effects, constipation cardiovascular effects.
bradycardia heart block CHF
class 3 beta blockers toxicity
impotenece , exacerbation of cold and asthma cardiovascular effects (av block bradcardia, chf ) Cns effects sedation sleep alternations. may mask the signs of hypoglycemia . metopalol can cause dyslipidemia propranolol can exacerbate vasospasm in prizmetal agony
contra indiacated in cocane users
class 1A toxicity
cinchonism ( headace tinnitus with quinidine) reversable
sale like syndrome ( procamide )heat failer ( disopyrimide ) thromboctyopenia , tornadoes de point
class 1 b toxicity
cns stimulation / depression, cardiovascular depression.
class 1 c toxicity
proarrythmia especially post mi ( contraindicated) ic
