Fármacos Osteoporosis Flashcards

1
Q

MA de bisfosfonatos

A

Disminuyen act de osteoclasto

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2
Q

Ibandronato reduce solamente

A

riesgo de columna

3mg/trimestral

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3
Q

Alendronato y risedronato reducen fracturas de

A

todo, hasta muneca

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4
Q

Ac zoledrónico reduce riesgo de

A

todo, 5mg al ano

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5
Q

EA de bisfosfonatos

A

RGE
Osteonecrosis de mandíbula
Fracturas transv de fémur en barra de tiza

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6
Q

Etidronato efecto en..

A

Solo en fracturas vertebrales

EA osteomalacia focal

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7
Q

MA de SERM

A

Bajan RANKL y TNFa (citocinas) de osteoclastos

Sólo RALOXIFENO

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8
Q

Raloxifeno reduce solamente el riesgo de..

A

fractura vertebral 30-50%

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9
Q

Dosis y EA raloxifeno

A

60 mg/día

Sofocos, calambres, riesgo de TVP

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10
Q

Estrógenos reducen..

A

3 tipos de fracturas

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11
Q

Estrógenos solo se aprueban

A

para prevenir climaterio

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12
Q

Denosumab MA

A

Anti RANKL (análogo de osteoprogerina)

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13
Q

Denosumab disminuye..

A

los 3 tipos de fracturas

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14
Q

Denosumab dosis

A

60 mg/ cada 6 meses

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15
Q

CI de BF

A

No usar en px con IRC, denosumab SÍ

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16
Q

Odanacatib es

A

inhibidor de la catepsina K, evita degradación de colageno 1

17
Q

único anabólico (formador de hueso)

A

Teriparatide, análogo de PTH 1-34

18
Q

Teriparatide dosis

A

20 ug/día SC, se da intermitente

19
Q

Teriparatide disminuye riesgo de fracturas en ..

A

columna>no vertebral> cadera

INDICADO SOLO SI YA HUBO FRACTURA

CI en riesgo de osteosarcoma

20
Q

Tx de osteoporosis por glucocorticoides

A

teriparatide es el mejor

21
Q

Mejor tx para osteoporosis masculina si el px tiene ca de próstata

A

Denosumab